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Background <p>Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional study examined the association between the functional, clinical, and radiographic characteristics of primary knee osteoarthritis and both bone mineral density and serum vitamin D levels in postmenopausal women.</p> Results <p>There was a significant correlation between vitamin D levels and the knee osteoarthritis flare-up score (KOFUS) score (<i>p</i> = 0.005). A substantial association was found between bone mineral density as reflected by the T score and knee osteoarthritis flare-up score, WOMAC score, and Kellgren and Lawrence scores: <i>p</i> = 0.014, <i>p</i> &lt; 0.05, and 0.001, respectively. A significant association was observed between bone mineral density (BMD) and the five-times sit-to-stand and 10-m walk speed tests.</p> Conclusion <p>Vitamin D deficiency has a significant impact on knee osteoarthritis severity and activity in postmenopausal women. A significant correlation exists between osteoporosis and flare-ups of knee osteoarthritis, along with both clinical and radiographic severity and functional status in postmenopausal women.</p>

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Relationship of vitamin D levels, bone mineral density, and primary knee osteoarthritis in postmenopausal women: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月25日

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  • Sahar Waheed El-Shafaey,
  • Abdel Wahab Shams El Deen EL Brashy,
  • Mohamed H. Faheem,
  • Noha Hosni Ibrahim

摘要

Background

Osteoarthritis (OA) and osteoporosis (OP) are the two predominant skeletal diseases linked to aging. The relationship between knee osteoarthritis, osteoporosis, and vitamin D insufficiency is not yet well comprehended and continues to be a topic of debate. This cross-sectional study examined the association between the functional, clinical, and radiographic characteristics of primary knee osteoarthritis and both bone mineral density and serum vitamin D levels in postmenopausal women.

Results

There was a significant correlation between vitamin D levels and the knee osteoarthritis flare-up score (KOFUS) score (p = 0.005). A substantial association was found between bone mineral density as reflected by the T score and knee osteoarthritis flare-up score, WOMAC score, and Kellgren and Lawrence scores: p = 0.014, p < 0.05, and 0.001, respectively. A significant association was observed between bone mineral density (BMD) and the five-times sit-to-stand and 10-m walk speed tests.

Conclusion

Vitamin D deficiency has a significant impact on knee osteoarthritis severity and activity in postmenopausal women. A significant correlation exists between osteoporosis and flare-ups of knee osteoarthritis, along with both clinical and radiographic severity and functional status in postmenopausal women.