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Background <p>Fibromyalgia syndrome (FMS) and insulin resistance (IR) may share common pathophysiological features. We aimed to investigate the role of IR among FMS patients and investigate its relation to various mutations in the catechol-O-methyltransferase (COMT) gene.</p> Methods and results <p>A case–control study which included 120 women (60 diagnosed as having FMS and 60 healthy women as a control group) aged from 22 to 40&#xa0;years was conducted. Patients had significantly increased HbA1C% (5.49 ± 0.35) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (1.74 ± 1.23) than controls (4.99 ± 0.27 and 0.92 ± 0.15, respectively) (<i>p</i> &lt; 0.001). The patients with the COMT A/A genotype had significantly higher mean values of the symptom severity score, painDETECT, McGill Pain, visual analog scale, Fibromyalgia Impact Questionnaire, and Small Fiber Neuropathy Screening List (<i>p</i> = 0.004, 0.004, 0.013, 0.019, 0.005, and 0.001, respectively).</p> Conclusion <p>IR was significantly higher among FMS patients, and patients with the COMT A/A allele had greater pain sensitivity. Thus, IR may have an add-on effect on pain in FM.</p>

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Insulin resistance in non-diabetic premenopausal female patients with fibromyalgia: relation to disease characteristics

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  • 发表日期：

    2025年6月23日

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  • Noha Elsawy,
  • Marwa Hassan,
  • Rasha Ghazala,
  • Riham Hamed,
  • Rehab Elnemr

摘要

Background

Fibromyalgia syndrome (FMS) and insulin resistance (IR) may share common pathophysiological features. We aimed to investigate the role of IR among FMS patients and investigate its relation to various mutations in the catechol-O-methyltransferase (COMT) gene.

Methods and results

A case–control study which included 120 women (60 diagnosed as having FMS and 60 healthy women as a control group) aged from 22 to 40 years was conducted. Patients had significantly increased HbA1C% (5.49 ± 0.35) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (1.74 ± 1.23) than controls (4.99 ± 0.27 and 0.92 ± 0.15, respectively) (p < 0.001). The patients with the COMT A/A genotype had significantly higher mean values of the symptom severity score, painDETECT, McGill Pain, visual analog scale, Fibromyalgia Impact Questionnaire, and Small Fiber Neuropathy Screening List (p = 0.004, 0.004, 0.013, 0.019, 0.005, and 0.001, respectively).

Conclusion

IR was significantly higher among FMS patients, and patients with the COMT A/A allele had greater pain sensitivity. Thus, IR may have an add-on effect on pain in FM.