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Background <p>Juvenile idiopathic arthritis (JIA) refers to all types of arthritis that begin before the age of 16 and last more than 6&#xa0;weeks, with no known cause. The 14-3-3 η eta protein is a new biomarker linked to the development of rheumatoid arthritis and joint destruction. We sought to evaluate the 14-3-3 η eta protein’s potential as a diagnostic biomarker for JIA and its correlation with both functional outcome and disease activity.</p> Results <p>Significant levels of 14-3-3 η eta protein were found in rheumatoid factor (RF)-positive polyarticular JIA and RF-negative polyarticular JIA patients. Enthesitis-related arthritis (ERA) is associated with the lowest value of 14-3-3 η eta. 14-3-3 eta protein was significantly positively linked with CHAQ and JADAS 27 (<i>p</i> = 0.008 &amp; 0.001, respectively).</p> Conclusion <p>The 14-3-3 η eta protein could be used as a biomarker to diagnose and monitor JIA. Significant levels of 14-3-3 η eta protein can be found in RF-positive polyarticular JIA and RF-negative polyarticular JIA patients. The 14-3-3 η eta protein correlates positively with disease activity and functional outcome in JIA.</p>

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Study of 14-3-3 η eta protein in juvenile idiopathic arthritis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月7日

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  • Khaled Omar Elfarouk Zaiton,
  • Yasser Abd-Elaziz Abd-Elhamid,
  • Nashwa Ismail Hashaad,
  • Inas A Ahmed,
  • Noha Hosni Ibrahim

摘要

Background

Juvenile idiopathic arthritis (JIA) refers to all types of arthritis that begin before the age of 16 and last more than 6 weeks, with no known cause. The 14-3-3 η eta protein is a new biomarker linked to the development of rheumatoid arthritis and joint destruction. We sought to evaluate the 14-3-3 η eta protein’s potential as a diagnostic biomarker for JIA and its correlation with both functional outcome and disease activity.

Results

Significant levels of 14-3-3 η eta protein were found in rheumatoid factor (RF)-positive polyarticular JIA and RF-negative polyarticular JIA patients. Enthesitis-related arthritis (ERA) is associated with the lowest value of 14-3-3 η eta. 14-3-3 eta protein was significantly positively linked with CHAQ and JADAS 27 (p = 0.008 & 0.001, respectively).

Conclusion

The 14-3-3 η eta protein could be used as a biomarker to diagnose and monitor JIA. Significant levels of 14-3-3 η eta protein can be found in RF-positive polyarticular JIA and RF-negative polyarticular JIA patients. The 14-3-3 η eta protein correlates positively with disease activity and functional outcome in JIA.