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Background <p>Reinke’s oedema (RE) is a chronic laryngeal condition linked to irritants. While smoking is a primary factor, the role of <i>Helicobacter pylori (H. pylori)</i> remains debated.</p> Objective <p>To explore the potential association between <i>H. pylori</i> seropositivity and Reinke’s oedema.</p> Methods <p>A case-control study was conducted with 52 participants (26 cases with RE; 26 controls). All underwent a comprehensive voice assessment and <i>H. pylori</i> IgG serology.</p> Results <p><i>H. pylori</i> seropositivity was significantly higher in the RE group (69.2%) compared to controls (19.2%, <i>P</i> &lt; 0.001). After adjusting for smoking and voice abuse, <i>H. pylori</i> infection was associated with a 6.03-fold increase in the odds of RE.</p> Conclusion <p><i>H. pylori</i> seropositivity is strongly associated with Reinke’s oedema, suggesting a potential role for reflux-mediated inflammatory damage in its pathogenesis.</p>

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Association between helicobacter pylori seropositivity and Reinke’s edema: a case-control study

  • 期刊论文

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  • 发表日期：

    2026年7月3日

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  • Fatma Wafik Shahin,
  • Effat Ahmed Zaky,
  • Asmaa Khalf Kamel,
  • Marwa Mohsen,
  • Marwa Omar Gamal,
  • Doaa Mohammed Ali

摘要

Background

Reinke’s oedema (RE) is a chronic laryngeal condition linked to irritants. While smoking is a primary factor, the role of Helicobacter pylori (H. pylori) remains debated.

Objective

To explore the potential association between H. pylori seropositivity and Reinke’s oedema.

Methods

A case-control study was conducted with 52 participants (26 cases with RE; 26 controls). All underwent a comprehensive voice assessment and H. pylori IgG serology.

Results

H. pylori seropositivity was significantly higher in the RE group (69.2%) compared to controls (19.2%, P < 0.001). After adjusting for smoking and voice abuse, H. pylori infection was associated with a 6.03-fold increase in the odds of RE.

Conclusion

H. pylori seropositivity is strongly associated with Reinke’s oedema, suggesting a potential role for reflux-mediated inflammatory damage in its pathogenesis.