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Background <p>Cortical auditory evoked potentials (CAEPs) are objective measures of auditory cortical activity that provide insight into the integrity of central auditory pathways. They have an important role in distinguishing between different types of hearing disorders. However, their clinical applicability in differentiating sensorineural hearing loss (SNHL) from auditory neuropathy spectrum disorders (ANSD) remains under investigation.</p> Aim <p>To evaluate and compare CAEP parameters in individuals with normal hearing, SNHL, and ANSD.</p> Methods <p>This study included 90 participants divided into three groups: normal-hearing, patients with SNHL, and patients with ANSD. CAEPs were recorded using tone burst of 2000&#xa0;Hz, and the latencies and amplitudes of the N1 and P2 components were recorded and analyzed across groups. Statistical analysis was performed to detect differences in waveform latency and amplitude.</p> Results <p>Normal-hearing participants demonstrated robust and replicable CAEP responses at 30 dBnHL. The SNHL group showed significantly delayed latencies and reduced amplitudes compared with controls. The ANSD group revealed highly variable responses, with some cases showing absent or atypical waveforms. These differences were statistically significant among the three groups.</p> Conclusion <p>CAEPs provide valuable insight into cortical auditory processing and can complement other tests in assessing hearing disorders as in ANSD, although they cannot reliably differentiate between SNHL and ANSD.</p>

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Study of cortical auditory evoked potentials in patients with normal hearing, sensorineural hearing loss, and auditory neuropathy spectrum disorders

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Naema Mohamed Ismail,
  • Hanaa Ahmed Fadel,
  • Amal Taha Ali

摘要

Background

Cortical auditory evoked potentials (CAEPs) are objective measures of auditory cortical activity that provide insight into the integrity of central auditory pathways. They have an important role in distinguishing between different types of hearing disorders. However, their clinical applicability in differentiating sensorineural hearing loss (SNHL) from auditory neuropathy spectrum disorders (ANSD) remains under investigation.

Aim

To evaluate and compare CAEP parameters in individuals with normal hearing, SNHL, and ANSD.

Methods

This study included 90 participants divided into three groups: normal-hearing, patients with SNHL, and patients with ANSD. CAEPs were recorded using tone burst of 2000 Hz, and the latencies and amplitudes of the N1 and P2 components were recorded and analyzed across groups. Statistical analysis was performed to detect differences in waveform latency and amplitude.

Results

Normal-hearing participants demonstrated robust and replicable CAEP responses at 30 dBnHL. The SNHL group showed significantly delayed latencies and reduced amplitudes compared with controls. The ANSD group revealed highly variable responses, with some cases showing absent or atypical waveforms. These differences were statistically significant among the three groups.

Conclusion

CAEPs provide valuable insight into cortical auditory processing and can complement other tests in assessing hearing disorders as in ANSD, although they cannot reliably differentiate between SNHL and ANSD.