Scholarlink

Aim of the work <p>This study assesses the limitations of transoral laser microsurgery (TLM) for early-stage laryngeal cancer involving the anterior commissure (AC), specifically examining the relationship between recurrence and thyroid cartilage invasion.</p> Patients and methods <p>A retrospective review of 32 T1–T2 glottic carcinoma patients treated with TLM between May 2023 and April 2025 analyzed recurrence and progression over 3–24&#xa0;months. Concurrently, a cross-sectional analysis of five laryngectomy specimens from recurrent cases evaluated AC involvement and thyroid cartilage invasion.</p> Results <p>The cohort comprised 19 T1 and 13 T2 tumors. Recurrence occurred in 22 patients (54%), with 14 (63.6%) recurring at the same stage and 8 (36.4%) progressing. Salvage treatment consisted of 15 conservative surgeries (68.2%) and 7 total laryngectomies (31.8%). Histological analysis of all five laryngectomy specimens revealed tumor involvement of the cartilage.</p> Conclusions <p>AC involvement significantly impacts prognosis in early-stage laryngeal cancer. Given the increased recurrence risk after TLM or DRT associated with AC, vocal cord, supraglottic, or subglottic involvement, and the potential need for total laryngectomy, conservative surgical approaches should be considered cautiously in these cases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The limitations of trans-oral endoscopic laser resection in the management of laryngeal cancer with anterior commissure involvement: retrospective, cross sectional studies and review of clinical experience

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月9日

查看全文
  • Mohamed Rifai,
  • Magdy M. Mansy,
  • Muhammed AbdAllateef,
  • Mena Esmat Abdelmalek

摘要

Aim of the work

This study assesses the limitations of transoral laser microsurgery (TLM) for early-stage laryngeal cancer involving the anterior commissure (AC), specifically examining the relationship between recurrence and thyroid cartilage invasion.

Patients and methods

A retrospective review of 32 T1–T2 glottic carcinoma patients treated with TLM between May 2023 and April 2025 analyzed recurrence and progression over 3–24 months. Concurrently, a cross-sectional analysis of five laryngectomy specimens from recurrent cases evaluated AC involvement and thyroid cartilage invasion.

Results

The cohort comprised 19 T1 and 13 T2 tumors. Recurrence occurred in 22 patients (54%), with 14 (63.6%) recurring at the same stage and 8 (36.4%) progressing. Salvage treatment consisted of 15 conservative surgeries (68.2%) and 7 total laryngectomies (31.8%). Histological analysis of all five laryngectomy specimens revealed tumor involvement of the cartilage.

Conclusions

AC involvement significantly impacts prognosis in early-stage laryngeal cancer. Given the increased recurrence risk after TLM or DRT associated with AC, vocal cord, supraglottic, or subglottic involvement, and the potential need for total laryngectomy, conservative surgical approaches should be considered cautiously in these cases.