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Background <p>Low back pain is a common and disabling condition with diverse etiologies, including infectious causes like brucellosis, particularly in endemic regions. We aimed to assess the seroprevalence of <i>Brucella</i> antibodies among high-risk patients presenting with low back pain.</p> Methods <p>A case-control study was conducted involving 66 patients with nonspecific low back pain and 30 age- and sex-matched controls without low back pain, all at high risk for brucellosis. Clinical data were collected, and Brucella antibodies were measured using the SERION ELISA Classic Brucella IgG/IgM/IgA kit.</p> Results <p><i>Brucella</i> seropositivity was significantly higher in those with low back pain (54.5%) compared to controls (23.3%) (<i>p</i> = 0.004). No significant differences were observed between seropositive and seronegative patients in demographic or clinical characteristics. Most patients with low back pain had rural backgrounds and occupational exposure to livestock.</p> Conclusion <p>Brucellosis could be an overlooked cause of low back pain in endemic areas. Early serological screening, especially using ELISA, is crucial for prompt diagnosis and to prevent complications.</p>

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Seroprevalence of Brucella antibodies in high-risk patients with low back pain: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月31日

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  • Elham Ahmed Hassan,
  • Abdel-Ghani A Soliman,
  • Mohamed Z Abd El-rhman,
  • Mohammed E Abd El-monem,
  • Noha A Masoud

摘要

Background

Low back pain is a common and disabling condition with diverse etiologies, including infectious causes like brucellosis, particularly in endemic regions. We aimed to assess the seroprevalence of Brucella antibodies among high-risk patients presenting with low back pain.

Methods

A case-control study was conducted involving 66 patients with nonspecific low back pain and 30 age- and sex-matched controls without low back pain, all at high risk for brucellosis. Clinical data were collected, and Brucella antibodies were measured using the SERION ELISA Classic Brucella IgG/IgM/IgA kit.

Results

Brucella seropositivity was significantly higher in those with low back pain (54.5%) compared to controls (23.3%) (p = 0.004). No significant differences were observed between seropositive and seronegative patients in demographic or clinical characteristics. Most patients with low back pain had rural backgrounds and occupational exposure to livestock.

Conclusion

Brucellosis could be an overlooked cause of low back pain in endemic areas. Early serological screening, especially using ELISA, is crucial for prompt diagnosis and to prevent complications.