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Objective <p>To investigate the evidence derived from randomized controlled Nutritional Intervention studies on telomere length.</p> Design <p>Systematic review of randomized controlled trials.</p> Data sources <p>MEDLINE-PubMed and Cochrane Library databases as well as a manual search of systematic reviews from their inception to June 2025.</p> Eligibility criteria for selecting studies <p>Randomized controlled trials comparing nutritional supplementation with a placebo or no treatment for changes on telomere length were included. Independent data extraction was conducted and study quality assessed.</p> Main outcome measures <p>Telomere length (TL).</p> Results <p>21 RCTs were identified. The most consistent evidence was found in supplementation with Selenium and CoQ10 and Vitamin D. Promising but weaker evidence was detected in supplementation with Walnuts, fish oil, high protein diet. Limited uncertain benefit from Mediterranean Diet, Astragalus, hydrogen-rich water, and vitamin B. There were no effects form almonds, pistachios, zinc supplementation, or caloric restriction. Generally, the evidence is limited by small sample sizes, short durations, heterogeneous TL measurement methods, and risk of bias.</p> Conclusions <p>Micronutrient supplementation with selenium, CoQ10, and vitamin D shows potential for healthy aging strategies. However, the available evidence is not yet sufficient for guideline-level recommendations, primarily due to the high risk of bias and substantial heterogeneity observed across the included randomized controlled trials (RCTs). Establishing a reliable evidence base will require large-scale, long-term RCTs that utilize standardized telomere assays.</p>

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Nutritional interventions and telomere length in humans: a systematic review of evidence from randomized controlled trials

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月17日

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  • Fardous Soliman,
  • Intessar Sultan,
  • Youssef Ahmed

摘要

Objective

To investigate the evidence derived from randomized controlled Nutritional Intervention studies on telomere length.

Design

Systematic review of randomized controlled trials.

Data sources

MEDLINE-PubMed and Cochrane Library databases as well as a manual search of systematic reviews from their inception to June 2025.

Eligibility criteria for selecting studies

Randomized controlled trials comparing nutritional supplementation with a placebo or no treatment for changes on telomere length were included. Independent data extraction was conducted and study quality assessed.

Main outcome measures

Telomere length (TL).

Results

21 RCTs were identified. The most consistent evidence was found in supplementation with Selenium and CoQ10 and Vitamin D. Promising but weaker evidence was detected in supplementation with Walnuts, fish oil, high protein diet. Limited uncertain benefit from Mediterranean Diet, Astragalus, hydrogen-rich water, and vitamin B. There were no effects form almonds, pistachios, zinc supplementation, or caloric restriction. Generally, the evidence is limited by small sample sizes, short durations, heterogeneous TL measurement methods, and risk of bias.

Conclusions

Micronutrient supplementation with selenium, CoQ10, and vitamin D shows potential for healthy aging strategies. However, the available evidence is not yet sufficient for guideline-level recommendations, primarily due to the high risk of bias and substantial heterogeneity observed across the included randomized controlled trials (RCTs). Establishing a reliable evidence base will require large-scale, long-term RCTs that utilize standardized telomere assays.