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Background <p>Tuberculosis may complicate imatinib therapy in patients with chronic myeloid leukemia. However, synchronous presentation of tuberculosis and CML is rare. Malignancy is a hypercoagulable state, especially in those who present with hyperleukocytosis and thrombocytosis.</p> Purpose <p>Still, the presentation of CML with deep vein thrombosis after 2&#xa0;months of initiation of tyrosine kinase inhibitor therapy is rare.</p> Methods <p>We present a case of a young female who presented with prolonged intermittent episodes of low-grade fever, abdominal distension, and cough. Diagnostic workup confirmed the simultaneous presence of peritoneal tuberculosis and CML in the chronic phase.</p> Results <p>Two months after starting the antitubercular drug and imatinib, she developed unilateral deep vein thrombosis of the right lower limb, which was possibly due to the underlying malignancy, as evaluation for other causes of thrombophilia was negative.</p> Conclusions <p>We report this case of extrapulmonary tuberculosis preceding the diagnosis of CML with atypical complications during treatment, which made the management of the disease challenging.</p>

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CML with extrapulmonary tuberculosis with secondary HLH associated with deep vein thrombosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月26日

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  • Anindita Paul,
  • Priyanka Samal,
  • Harshwardhan Bahirat,
  • Pritish Chandra Patra,
  • Ashutosh Samal,
  • Sarita Pradhan,
  • Tushar Pandey,
  • Soudamini Mahapatra,
  • Bhavani Mandava,
  • Naqash Suse,
  • Ajit Kumar Bishoyi

摘要

Background

Tuberculosis may complicate imatinib therapy in patients with chronic myeloid leukemia. However, synchronous presentation of tuberculosis and CML is rare. Malignancy is a hypercoagulable state, especially in those who present with hyperleukocytosis and thrombocytosis.

Purpose

Still, the presentation of CML with deep vein thrombosis after 2 months of initiation of tyrosine kinase inhibitor therapy is rare.

Methods

We present a case of a young female who presented with prolonged intermittent episodes of low-grade fever, abdominal distension, and cough. Diagnostic workup confirmed the simultaneous presence of peritoneal tuberculosis and CML in the chronic phase.

Results

Two months after starting the antitubercular drug and imatinib, she developed unilateral deep vein thrombosis of the right lower limb, which was possibly due to the underlying malignancy, as evaluation for other causes of thrombophilia was negative.

Conclusions

We report this case of extrapulmonary tuberculosis preceding the diagnosis of CML with atypical complications during treatment, which made the management of the disease challenging.