Scholarlink

Background <p>The Systemic Lupus Erythematosus Disease Activity-2000 Glucocorticoid Index (SLEDAI-2&#xa0;KG) accounts for glucocorticoids and possibly promising. The Physician Global Assessment (PGA) is subjective and debatable.</p> Objectives <p>Assessment of the validity of the SLEDAI-2&#xa0;KG, its association with the PGA, and their potential association with the disease damage.</p> Methods <p>A cross-sectional study included SLE patients managed at 2 tertiary centers in Egypt were conducted. The SLEDAI-2&#xa0;K was the gold standard score for assessment the disease activity. The SLEDAI-2&#xa0;KG incorporates glucocorticoids’ dosage through an ordinal weight. The PGA (scale: 0–3) was categorized according to the PGA international standardization consensus in SLE study (PISCOS).</p> Results <p>The study included 608 patients [546 (89.8%) females and [62 (10.2%) males; age at onset: 27.5 ± 8.5&#xa0;years; age at assessment: 31.4 ± 9.4&#xa0;years; disease duration: 6.1 ± 5.5&#xa0;years for females]. The mean SLEDAI-2&#xa0;K, SLEDAI-2&#xa0;KG, and PGA was 11.9 ± 9.3, 16 ± 10.5, and 1.2 ± 0.8, respectively. The correlation between both the SLEDAI-2&#xa0;KG (r: 0.96, <i>p</i> &lt; 0.001) and PGA (r: 0.5, <i>p</i> &lt; 0.001) and SLEDAI-2&#xa0;K was statistically significant. The association’s strength between both the SLEDAI-2&#xa0;KG and PGA and SLEDAI-2&#xa0;K declined among low activity-patients (SLEDAI-2&#xa0;K &lt; 6) [(r = 0,4; <i>p</i> &lt; 0.001) (r = 0.2; <i>p</i> = 0.02), respectively], and the SLEDAI-2&#xa0;KG and PGA were not associated in this subgroup (r: 0.07, <i>p </i>= 0.4). The agreement’s strength between the SLEDAI-2&#xa0;K and PISCOS-PGA was weak (kappa = 0.17, <i>p</i> &lt; 0.001). The SLEDAI-2&#xa0;K and SLEDAI-2&#xa0;KG were comparable predictors for damage and the PGA was a weaker predictor.</p> Conclusion <p>The SLEDAI-2&#xa0;KG and PGA correlated significantly with the SLEDAI-2&#xa0;K, yet the correlation’s strength declined among low disease activity-patients. The SLEDAI-2&#xa0;K and SLEDAI-2&#xa0;KG were comparable predictors for damage.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Validity of the Systemic Lupus Erythematosus Disease Activity 2000-Glucocorticoid Index, its association with the Physician Global Assessment, and potential association with disease damage

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月8日

查看全文
  • Basma M. Medhat,
  • Lobna A. Maged,
  • Doaa A. Teleb,
  • Sally S. Mohamed,
  • Angie Y. Afifi,
  • Dina M. T. Koptan,
  • Walaa Abdelrahman,
  • Dalia Dorgham,
  • Eman Hany Elsebaie,
  • Naglaa Afifi,
  • Sahar A. Ahmed,
  • Mervat E. Behairy,
  • Hala Ramadan

摘要

Background

The Systemic Lupus Erythematosus Disease Activity-2000 Glucocorticoid Index (SLEDAI-2 KG) accounts for glucocorticoids and possibly promising. The Physician Global Assessment (PGA) is subjective and debatable.

Objectives

Assessment of the validity of the SLEDAI-2 KG, its association with the PGA, and their potential association with the disease damage.

Methods

A cross-sectional study included SLE patients managed at 2 tertiary centers in Egypt were conducted. The SLEDAI-2 K was the gold standard score for assessment the disease activity. The SLEDAI-2 KG incorporates glucocorticoids’ dosage through an ordinal weight. The PGA (scale: 0–3) was categorized according to the PGA international standardization consensus in SLE study (PISCOS).

Results

The study included 608 patients [546 (89.8%) females and [62 (10.2%) males; age at onset: 27.5 ± 8.5 years; age at assessment: 31.4 ± 9.4 years; disease duration: 6.1 ± 5.5 years for females]. The mean SLEDAI-2 K, SLEDAI-2 KG, and PGA was 11.9 ± 9.3, 16 ± 10.5, and 1.2 ± 0.8, respectively. The correlation between both the SLEDAI-2 KG (r: 0.96, p < 0.001) and PGA (r: 0.5, p < 0.001) and SLEDAI-2 K was statistically significant. The association’s strength between both the SLEDAI-2 KG and PGA and SLEDAI-2 K declined among low activity-patients (SLEDAI-2 K < 6) [(r = 0,4; p < 0.001) (r = 0.2; p = 0.02), respectively], and the SLEDAI-2 KG and PGA were not associated in this subgroup (r: 0.07, p = 0.4). The agreement’s strength between the SLEDAI-2 K and PISCOS-PGA was weak (kappa = 0.17, p < 0.001). The SLEDAI-2 K and SLEDAI-2 KG were comparable predictors for damage and the PGA was a weaker predictor.

Conclusion

The SLEDAI-2 KG and PGA correlated significantly with the SLEDAI-2 K, yet the correlation’s strength declined among low disease activity-patients. The SLEDAI-2 K and SLEDAI-2 KG were comparable predictors for damage.