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<p>Breast cancer is the most prevalent cause of cancer-related deaths among women worldwide. Patients that get chemotherapy endure severe side effects and develop drug resistance. To optimize the immune system's ability to destroy breast cancer, several strategies have been developed. Natural product-based breast cancer treatments are also getting plenty of attention because of their low toxicity as well as their high efficacy and selectivity. From marine cyanobacteria <i>Moorena producens</i>, about 231 chemicals were discovered and categorized into 66 types. The role of <i>M. producens</i> constituents such as malyngamides, microcolins, dolastatins, apratoxins, apramides, lyngbyatoxins, guineamides, oscillatoxins, and majusculamides in the treatment of breast cancer is thoroughly reviewed in this article, which also highlights related mechanisms of action and potential difficulties. Additionally, it provides recommendations for future research directions.</p>

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A marvelous hope in the treatment of breast cancer: Moorena producens as an incredible source of bioactive metabolites with a variety of unique selective molecular mechanisms

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月21日

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  • Esraa M. Abdelhady,
  • Mona M. Hashem,
  • Mohammed N. A. Khalil,
  • Omar M. Sabry

摘要

Breast cancer is the most prevalent cause of cancer-related deaths among women worldwide. Patients that get chemotherapy endure severe side effects and develop drug resistance. To optimize the immune system's ability to destroy breast cancer, several strategies have been developed. Natural product-based breast cancer treatments are also getting plenty of attention because of their low toxicity as well as their high efficacy and selectivity. From marine cyanobacteria Moorena producens, about 231 chemicals were discovered and categorized into 66 types. The role of M. producens constituents such as malyngamides, microcolins, dolastatins, apratoxins, apramides, lyngbyatoxins, guineamides, oscillatoxins, and majusculamides in the treatment of breast cancer is thoroughly reviewed in this article, which also highlights related mechanisms of action and potential difficulties. Additionally, it provides recommendations for future research directions.