Scholarlink

Background <p>Preventable drug-related incidents (PDRIs) remain a major challenge to patient safety, particularly in hospitals that manage complex infectious diseases. However, data on their frequency and characteristics in such settings are scarce. This study estimated the incidence of PDRIs in a specialized infectious diseases hospital and identified the most frequent incident types.</p> Methods <p>This prospective study consecutively included adults (≥ 18&#xa0;years) admitted to the clinical ward of a tertiary infectious diseases hospital from June 13, 2019, to March 6, 2020, and followed them until discharge. Recruitment was originally planned for 12&#xa0;months but was interrupted after nine months due to COVID-19-related operational restrictions. PDRIs were assessed every seven days through systematic prescription review and classified using the Severity Assessment Code (SAC).</p> Results <p>A total of 212 hospitalized patients were analyzed, of whom 78.8% experienced at least one PDRI. Drug interactions, scheduling errors, dosage mistakes, and adverse drug reactions were the most frequent incidents. The incidence rate was highest during the first week of hospitalization and decreased thereafter. Higher PDRI rates were observed among adults aged 39–60&#xa0;years, females, patients with comorbidities, and those with infectious diagnoses such as Chagas disease, sporotrichosis, tuberculosis, and HIV/AIDS.</p> Conclusions <p>PDRIs were frequent and strongly associated with clinical complexity and early hospitalization. These findings underscore the critical role of clinical pharmacists in early intervention, systematic prescription monitoring, and implementation of preventive strategies to reduce medication-related harm in infectious disease settings.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Frequency and classification of drug-related incidents in an infectious disease ward of a high-complexity hospital

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月18日

查看全文
  • Eduardo Corsino Freire,
  • Paula Gabriela dos Santos Barreto,
  • Renato Barbosa Rezende,
  • André Luiz dos Santos,
  • Fernando de Oliveira Silva,
  • Vanessa Rodrigues Bezerra,
  • Pedro Emmanuel Alvarenga Americano do Brasil,
  • Juliana Arruda de Matos

摘要

Background

Preventable drug-related incidents (PDRIs) remain a major challenge to patient safety, particularly in hospitals that manage complex infectious diseases. However, data on their frequency and characteristics in such settings are scarce. This study estimated the incidence of PDRIs in a specialized infectious diseases hospital and identified the most frequent incident types.

Methods

This prospective study consecutively included adults (≥ 18 years) admitted to the clinical ward of a tertiary infectious diseases hospital from June 13, 2019, to March 6, 2020, and followed them until discharge. Recruitment was originally planned for 12 months but was interrupted after nine months due to COVID-19-related operational restrictions. PDRIs were assessed every seven days through systematic prescription review and classified using the Severity Assessment Code (SAC).

Results

A total of 212 hospitalized patients were analyzed, of whom 78.8% experienced at least one PDRI. Drug interactions, scheduling errors, dosage mistakes, and adverse drug reactions were the most frequent incidents. The incidence rate was highest during the first week of hospitalization and decreased thereafter. Higher PDRI rates were observed among adults aged 39–60 years, females, patients with comorbidities, and those with infectious diagnoses such as Chagas disease, sporotrichosis, tuberculosis, and HIV/AIDS.

Conclusions

PDRIs were frequent and strongly associated with clinical complexity and early hospitalization. These findings underscore the critical role of clinical pharmacists in early intervention, systematic prescription monitoring, and implementation of preventive strategies to reduce medication-related harm in infectious disease settings.