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Background <p>Acute kidney injury often occurs after ischemia<b>–</b>reperfusion and is one of the main kidney diseases with high mortality. Accordingly, the aim of the current study was evaluated and compare the effectiveness of treatment with platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in renal ischemia<b>–</b>reperfusion rat model.</p> Material and methods <p>Forty rats were grouped as control, ischemia/reperfusion, ischemia/reperfusion plus PRP and ischemia/reperfusion plus PRF. Kidney histopathology indexes and the level of kidney function biomarkers including, BUN, Creatinine, Na, K, LDH, ALP and inflammatory markers and also protein expression of KM1 assessed in all groups.</p> Results <p>The obtained results of the current study showed that kidney ischemia<b>–</b>reperfusion caused to significant increases of BUN and creatinine level which was in line with destruction of kidney tissue structure. The pro-inflammatory marker significantly increased in renal ischemia group compare to the control rats which was associated with up-regulation of KM1 protein in kidney tissue. PRF treatment group showed a more efficacy in improved renal function with suppressed inflammatory process and decreases KM1 gene expression compare to PRP administration.</p> Conclusion <p>The current study reported promising results regarding the more potent efficacy of PRF as a simple, safe, rapid and cost-effective treatment strategy in the treatment of renal dysfunction compare to the PRP.</p> Graphical Abstract <p></p>

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Efficacy of platelet-rich fibrin and platelet-rich plasma in mitigating renal ischemia–reperfusion injury targeting the KIM-1 protein

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月30日

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  • Maryam Radan,
  • Fereshteh Nejaddehbashi,
  • Khojasteh Hoseinynejad

摘要

Background

Acute kidney injury often occurs after ischemia–reperfusion and is one of the main kidney diseases with high mortality. Accordingly, the aim of the current study was evaluated and compare the effectiveness of treatment with platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in renal ischemia–reperfusion rat model.

Material and methods

Forty rats were grouped as control, ischemia/reperfusion, ischemia/reperfusion plus PRP and ischemia/reperfusion plus PRF. Kidney histopathology indexes and the level of kidney function biomarkers including, BUN, Creatinine, Na, K, LDH, ALP and inflammatory markers and also protein expression of KM1 assessed in all groups.

Results

The obtained results of the current study showed that kidney ischemia–reperfusion caused to significant increases of BUN and creatinine level which was in line with destruction of kidney tissue structure. The pro-inflammatory marker significantly increased in renal ischemia group compare to the control rats which was associated with up-regulation of KM1 protein in kidney tissue. PRF treatment group showed a more efficacy in improved renal function with suppressed inflammatory process and decreases KM1 gene expression compare to PRP administration.

Conclusion

The current study reported promising results regarding the more potent efficacy of PRF as a simple, safe, rapid and cost-effective treatment strategy in the treatment of renal dysfunction compare to the PRP.

Graphical Abstract