Scholarlink

Background <p>Ulcerative colitis (UC) is an autoimmune condition distinguished by prolonged inflammation of the intestinal mucosa with fluctuating periods of relapse and remission. This research was designed to evaluate the prospective alleviative impacts of muscone (3-methyl-1-cyclopentadecanone) on inflammatory processes and oxidative stress in the acetic acid (AA)-provoked UC in mice.</p> Methods <p>The experimental colitis was provoked by intrarectal injection of 200 μL of AA (6% volume/volume with 0.9% sterile saline). Mice were intrarectally (I.R.) administered with sulfasalazine “SSZ” (500&#xa0;mg/kg body weight “b.w”) or muscone (20 or 40&#xa0;mg/kg b.w) in 200 μL sterile saline at one hour (h), 6&#xa0;h, and 12&#xa0;h following the I.R. administration of AA. A day after the induction of UC, animals were humanely executed, and their colons were harvested for morphological, histological, immunohistochemical, along with biochemical assays.</p> Results <p>Muscone ameliorated the colitis severity in mice, as signified by a considerable decline (<i>P</i> &lt; 0.05) in colon weight-to-length ratio, macroscopic damage, and histological alterations. Furthermore, muscone increased considerably the colonic levels of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT), while decreasing the levels of malondialdehyde (MDA) and nitric oxide (NOx) in UC mice. Muscone also lowered significantly the levels of colonic NF-κB and COX-2, in addition to inhibiting the production of IL-17A and IL-23 in the colons of UC mice.</p> Conclusion <p>Muscone could serve as an efficacious treatment for alleviating the inflammatory processes in UC mice, as it inhibits NF-κB, IL-23/IL-17A axis, COX-2, and enhances the antioxidant defense system in colon tissues.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Muscone alleviated acetic acid-induced ulcerative colitis in mice through inhibiting NF-κB, IL-23/IL-17A axis, COX-2, and oxidative stress

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月5日

查看全文
  • Mohamed A. El-Sayed,
  • Gamal Ramadan,
  • Hend A. Mohammed

摘要

Background

Ulcerative colitis (UC) is an autoimmune condition distinguished by prolonged inflammation of the intestinal mucosa with fluctuating periods of relapse and remission. This research was designed to evaluate the prospective alleviative impacts of muscone (3-methyl-1-cyclopentadecanone) on inflammatory processes and oxidative stress in the acetic acid (AA)-provoked UC in mice.

Methods

The experimental colitis was provoked by intrarectal injection of 200 μL of AA (6% volume/volume with 0.9% sterile saline). Mice were intrarectally (I.R.) administered with sulfasalazine “SSZ” (500 mg/kg body weight “b.w”) or muscone (20 or 40 mg/kg b.w) in 200 μL sterile saline at one hour (h), 6 h, and 12 h following the I.R. administration of AA. A day after the induction of UC, animals were humanely executed, and their colons were harvested for morphological, histological, immunohistochemical, along with biochemical assays.

Results

Muscone ameliorated the colitis severity in mice, as signified by a considerable decline (P < 0.05) in colon weight-to-length ratio, macroscopic damage, and histological alterations. Furthermore, muscone increased considerably the colonic levels of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT), while decreasing the levels of malondialdehyde (MDA) and nitric oxide (NOx) in UC mice. Muscone also lowered significantly the levels of colonic NF-κB and COX-2, in addition to inhibiting the production of IL-17A and IL-23 in the colons of UC mice.

Conclusion

Muscone could serve as an efficacious treatment for alleviating the inflammatory processes in UC mice, as it inhibits NF-κB, IL-23/IL-17A axis, COX-2, and enhances the antioxidant defense system in colon tissues.