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Background <p>Plants have long been recognized as a rich source for medicinal agents, albeit many plant species have yet to be investigated. The genus <i>Chlorophytum</i> comprises over 215 species of perennial, rhizomatous herbs. The chemical composition and bioactivities of <i>Chlorophytum krookianum</i> remain uncharacterized in the existing scholar literature. This work investigates the phytochemistry and anticancer potential of <i>C. krookianum</i>.</p> Results <p>Phytochemical investigation of the unexplored <i>C. krookianum</i> aerial parts afforded the isolation and identification of eight compounds: <i>β-</i>sitosterol (<b>1</b>), stigmasterol (<b>2</b>), <i>β</i>-sitosterol-3-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>3</b>), hydroxytyrosol (<b>4</b>), isovitexin (<b>5</b>), vicenin 2 (<b>6</b>), (25<i>S</i>)-gitonin (<b>7</b>), and vitexin-2″-<i>O</i>-rhamnoside (<b>8</b>). Dichloromethane and <i>n</i>-hexane fractions of <i>C. krookianum</i> aerial parts exhibited anticancer activity against breast (MDA-MB-231) and tongue (HNO-97) carcinoma cell lines. GC–MS analysis of the <i>n</i>-hexane fraction afforded the tentative identification of 41 metabolites with methyl palmitate, methyl 2,4-dimethyltetradecanoate, 6,10,14-trimethyl-2-pentadecanone, lanosterol, and 13-docosenamide as major compounds.</p> Conclusion <p><i>C. krookianum</i> aerial parts, particularly the dichloromethane and <i>n</i>-hexane fractions, could be a potential source for anticancer activity as significant percentage inhibitions are obtained.</p>

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Phytochemical investigation and anticancer assessment of Chlorophytum krookianum

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月15日

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  • Menna Elemairy,
  • Enas I. A. Mohamed,
  • Abeer Moawad,
  • Rabab Mohammed

摘要

Background

Plants have long been recognized as a rich source for medicinal agents, albeit many plant species have yet to be investigated. The genus Chlorophytum comprises over 215 species of perennial, rhizomatous herbs. The chemical composition and bioactivities of Chlorophytum krookianum remain uncharacterized in the existing scholar literature. This work investigates the phytochemistry and anticancer potential of C. krookianum.

Results

Phytochemical investigation of the unexplored C. krookianum aerial parts afforded the isolation and identification of eight compounds: β-sitosterol (1), stigmasterol (2), β-sitosterol-3-O-β-D-glucopyranoside (3), hydroxytyrosol (4), isovitexin (5), vicenin 2 (6), (25S)-gitonin (7), and vitexin-2″-O-rhamnoside (8). Dichloromethane and n-hexane fractions of C. krookianum aerial parts exhibited anticancer activity against breast (MDA-MB-231) and tongue (HNO-97) carcinoma cell lines. GC–MS analysis of the n-hexane fraction afforded the tentative identification of 41 metabolites with methyl palmitate, methyl 2,4-dimethyltetradecanoate, 6,10,14-trimethyl-2-pentadecanone, lanosterol, and 13-docosenamide as major compounds.

Conclusion

C. krookianum aerial parts, particularly the dichloromethane and n-hexane fractions, could be a potential source for anticancer activity as significant percentage inhibitions are obtained.