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<p>Hepatitis is a significant cause of severe liver diseases, including cirrhosis, liver failure, and hepatocellular carcinoma. Current strategies include antiviral drugs, vaccination, and liver transplantation; however, a potential therapeutic strategy is to modulate the ubiquitin-specific proteases (USPs) to develop innovative therapeutic approaches. USPs are a class of deubiquitinating enzymes that play an important role in modulating protein turnover, cell signaling, and immune responses. Recent studies have provided new insights into hepatitis-related therapies for these USPs, as they influence the major signaling pathways and protein synthesis concerning viral replication and liver inflammation. This review provides a detailed analysis of USPs in hepatitis and its manifestations. USPs, such as USP18 in viral hepatitis, modulate the interferon signaling and hence play a critical role in influencing treatment outcomes. USP18, USP15, and USP37 interact with viral proteins, promoting HB&amp;C replication and immune escape. In autoimmune hepatitis, USP4 regulation reduces fibrosis and inflammation, while USP10 promotes autophagy, mitigating nonalcoholic steatohepatitis-related steatosis and fibrosis. This study clarifies the molecular mechanisms involved in USP-mediated pathways and may inform the development of therapeutic approaches for hepatitis and benefit patient recovery and public health.</p>

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Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月28日

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  • Kavita Goyal,
  • Muhammad Afzal,
  • Ashok Kumar Bishoyi,
  • R. Roopashree,
  • Suman Saini,
  • R. S. K. Sharma,
  • Piyus Kumar Pathak,
  • Ashish Singh Chauhan,
  • Surendar Aravindhan,
  • Mohd Imran,
  • Abida Abida Abida

摘要

Hepatitis is a significant cause of severe liver diseases, including cirrhosis, liver failure, and hepatocellular carcinoma. Current strategies include antiviral drugs, vaccination, and liver transplantation; however, a potential therapeutic strategy is to modulate the ubiquitin-specific proteases (USPs) to develop innovative therapeutic approaches. USPs are a class of deubiquitinating enzymes that play an important role in modulating protein turnover, cell signaling, and immune responses. Recent studies have provided new insights into hepatitis-related therapies for these USPs, as they influence the major signaling pathways and protein synthesis concerning viral replication and liver inflammation. This review provides a detailed analysis of USPs in hepatitis and its manifestations. USPs, such as USP18 in viral hepatitis, modulate the interferon signaling and hence play a critical role in influencing treatment outcomes. USP18, USP15, and USP37 interact with viral proteins, promoting HB&C replication and immune escape. In autoimmune hepatitis, USP4 regulation reduces fibrosis and inflammation, while USP10 promotes autophagy, mitigating nonalcoholic steatohepatitis-related steatosis and fibrosis. This study clarifies the molecular mechanisms involved in USP-mediated pathways and may inform the development of therapeutic approaches for hepatitis and benefit patient recovery and public health.