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Background <p>Transverse sinus stenting represents a promising therapeutic intervention for idiopathic intracranial hypertension (IIH), providing significant symptom relief while maintaining a favorable safety profile. The objective of this study was to evaluate the effectiveness of transverse sinus stenting in patients with idiopathic intracranial hypertension (IIH) and transverse sinus stenosis. A prospective, single-arm interventional clinical trial was conducted on twenty adult patients with refractory IIH and transverse sinus stenosis (≥ 50% luminal narrowing, ≥ 8&#xa0;mmHg pressure gradient), all of whom underwent endovascular stenting. Pre-procedural imaging included MRI/MRV and retrograde cerebral venography with manometry. Stenting was performed under general anesthesia via femoral and jugular access. Clinical outcomes (headache, tinnitus, papilledema) were assessed at baseline and three and six months post-procedure using validated scoring scales.</p> Results <p>The mean age of study participants was 34.7 ± 8.93&#xa0;years. Males constituted 15% of the sample, while females accounted for 85%. The mean BMI was 34.19 ± 7.07&#xa0;kg/m<sup>2</sup>. Unilateral stenting was performed in 85% of cases. Headache severity significantly improved, with the proportion of moderate to severe cases decreasing from 50% pre-stenting to 0% at six months post-procedure (<i>p</i> &lt; 0.001). Tinnitus resolved in 95% of patients (<i>p</i> &lt; 0.001). The prevalence of papilledema declined from 75 to 10% at six months (<i>p</i> &lt; 0.001). The mean pressure gradient decreased from 24.8 ± 5.6&#xa0;mmHg to 4.6 ± 0.94&#xa0;mmHg (<i>p</i> &lt; 0.001). Patients with papilledema experienced a significantly greater reduction in pressure gradient compared to those without papilledema (<i>p</i> &lt; 0.001 and <i>p</i> = 0.002, respectively).</p> Conclusions <p>Transverse sinus stenting effectively alleviates symptoms and significantly reduces venous pressure gradients in patients with refractory IIH. Larger multicenter studies with prolonged follow-up are required to validate these findings.</p>

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Transverse sinus stenting for treatment of idiopathic intracranial hypertension

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月13日

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  • Mohammed A. Ma’anawey,
  • Wessam sherin shokry,
  • Amr M. Abdelsamad,
  • Mostafa Farid

摘要

Background

Transverse sinus stenting represents a promising therapeutic intervention for idiopathic intracranial hypertension (IIH), providing significant symptom relief while maintaining a favorable safety profile. The objective of this study was to evaluate the effectiveness of transverse sinus stenting in patients with idiopathic intracranial hypertension (IIH) and transverse sinus stenosis. A prospective, single-arm interventional clinical trial was conducted on twenty adult patients with refractory IIH and transverse sinus stenosis (≥ 50% luminal narrowing, ≥ 8 mmHg pressure gradient), all of whom underwent endovascular stenting. Pre-procedural imaging included MRI/MRV and retrograde cerebral venography with manometry. Stenting was performed under general anesthesia via femoral and jugular access. Clinical outcomes (headache, tinnitus, papilledema) were assessed at baseline and three and six months post-procedure using validated scoring scales.

Results

The mean age of study participants was 34.7 ± 8.93 years. Males constituted 15% of the sample, while females accounted for 85%. The mean BMI was 34.19 ± 7.07 kg/m2. Unilateral stenting was performed in 85% of cases. Headache severity significantly improved, with the proportion of moderate to severe cases decreasing from 50% pre-stenting to 0% at six months post-procedure (p < 0.001). Tinnitus resolved in 95% of patients (p < 0.001). The prevalence of papilledema declined from 75 to 10% at six months (p < 0.001). The mean pressure gradient decreased from 24.8 ± 5.6 mmHg to 4.6 ± 0.94 mmHg (p < 0.001). Patients with papilledema experienced a significantly greater reduction in pressure gradient compared to those without papilledema (p < 0.001 and p = 0.002, respectively).

Conclusions

Transverse sinus stenting effectively alleviates symptoms and significantly reduces venous pressure gradients in patients with refractory IIH. Larger multicenter studies with prolonged follow-up are required to validate these findings.