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Objective <p>To assess the frequency and severity of potential drug–drug interactions (pDDIs) among hospitalized children with liver diseases.</p> Methods <p>This observational longitudinal inpatient surveillance study included children with liver diseases who were admitted over four months. pDDIs were assessed using two DDI screening programs: Lexicomp and Medscape Interaction Checker.</p> Results <p>The study included 50 patients. Most patients had cholestatic disorders of infancy (76%). Twenty patients (40%) experienced at least one pDDI. The total number of pDDIs identified was 52. Mild pDDIs accounted for 34.5%, moderate pDDIs for 54%, and severe pDDIs for 11.5%. The most commonly prescribed drugs were fat-soluble vitamins, whereas the drugs most frequently involved in pDDIs were fluconazole and corticosteroids. In most cases, the recommended action was monitoring only. Interactions involving fluconazole and other drugs require monitoring for QT prolongation. The number of severe pDDIs per patient was significantly higher in older patients (<i>P</i> = 0.007) and in underweight patients (<i>P</i> = 0.044). Patients who had undergone the Kasai procedure had a longer hospital stay and a higher frequency of DDIs.</p> Conclusion <p>pDDIs are common among hospitalized children with liver diseases, with most being of moderate severity. Fluconazole was the drug most commonly associated with severe pDDIs and requires monitoring for QT prolongation. The frequency of severe pDDIs was associated with older age and underweight status.</p>

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Drug–drug interactions in hospitalized children with liver diseases: incidence, severity, and risk factors

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月16日

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  • Engy A. Mogahed,
  • Noha Adel Yassin,
  • Ehab A. Atef,
  • Basma A. Abd El Zaher,
  • Rania Ramzi,
  • Merna Adel Aziz,
  • Haytham Ghita

摘要

Objective

To assess the frequency and severity of potential drug–drug interactions (pDDIs) among hospitalized children with liver diseases.

Methods

This observational longitudinal inpatient surveillance study included children with liver diseases who were admitted over four months. pDDIs were assessed using two DDI screening programs: Lexicomp and Medscape Interaction Checker.

Results

The study included 50 patients. Most patients had cholestatic disorders of infancy (76%). Twenty patients (40%) experienced at least one pDDI. The total number of pDDIs identified was 52. Mild pDDIs accounted for 34.5%, moderate pDDIs for 54%, and severe pDDIs for 11.5%. The most commonly prescribed drugs were fat-soluble vitamins, whereas the drugs most frequently involved in pDDIs were fluconazole and corticosteroids. In most cases, the recommended action was monitoring only. Interactions involving fluconazole and other drugs require monitoring for QT prolongation. The number of severe pDDIs per patient was significantly higher in older patients (P = 0.007) and in underweight patients (P = 0.044). Patients who had undergone the Kasai procedure had a longer hospital stay and a higher frequency of DDIs.

Conclusion

pDDIs are common among hospitalized children with liver diseases, with most being of moderate severity. Fluconazole was the drug most commonly associated with severe pDDIs and requires monitoring for QT prolongation. The frequency of severe pDDIs was associated with older age and underweight status.