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Objective <p>To analyze the research status, hotspots, and trends in hyperbilirubinemia treatment, providing reference for future research and clinical practice.</p> Methods <p>Relevant studies on hyperbilirubinemia treatment from January 1, 2000, to April 13, 2025, were retrieved from the Web of Science Core Collection. CiteSpace 6.4.R1 and Excel 2021 were used for visual analysis of annual publications, institutions, countries, co-cited literature, and keywords.</p> Results <p>A total of 1735 articles were included. Research interest remains high, with phototherapy and exchange transfusion as the main treatments. Recently, adjunctive therapies such as pharmacological agents, probiotics, kangaroo care, massage, and hydration therapy have emerged. The USA leads in publication volume, with University of California System as the top institution. Keyword clustering identified newborns and premature infants as primary subjects, and bilirubin-related indicators as key evaluation metrics.</p> Conclusions <p>Phototherapy and exchange transfusion remain core therapeutic interventions, while probiotics, pharmacotherapeutics, and non-invasive modalities constitute emerging paradigms with translational potential; future research should prioritize the evidence-based integration of multimodal regimens to establish a dual-dimension framework optimizing therapeutic efficacy and safety profiles.</p>

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Research hotspots in the treatment of neonatal hyperbilirubinemia: a bibliometric study and visualization analysis via CiteSpace

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月23日

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  • Juan Liu,
  • Jiacheng Wang,
  • Xin Li,
  • Xinping Huang,
  • Chunxiao Nan,
  • Shan Wang,
  • Wei Pang

摘要

Objective

To analyze the research status, hotspots, and trends in hyperbilirubinemia treatment, providing reference for future research and clinical practice.

Methods

Relevant studies on hyperbilirubinemia treatment from January 1, 2000, to April 13, 2025, were retrieved from the Web of Science Core Collection. CiteSpace 6.4.R1 and Excel 2021 were used for visual analysis of annual publications, institutions, countries, co-cited literature, and keywords.

Results

A total of 1735 articles were included. Research interest remains high, with phototherapy and exchange transfusion as the main treatments. Recently, adjunctive therapies such as pharmacological agents, probiotics, kangaroo care, massage, and hydration therapy have emerged. The USA leads in publication volume, with University of California System as the top institution. Keyword clustering identified newborns and premature infants as primary subjects, and bilirubin-related indicators as key evaluation metrics.

Conclusions

Phototherapy and exchange transfusion remain core therapeutic interventions, while probiotics, pharmacotherapeutics, and non-invasive modalities constitute emerging paradigms with translational potential; future research should prioritize the evidence-based integration of multimodal regimens to establish a dual-dimension framework optimizing therapeutic efficacy and safety profiles.