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Background <p>Persistent pulmonary hypertension of the newborn (PPHN) is characterized by high pulmonary vascular resistance, causing right-to-left blood shunting and respiratory distress. High-frequency oscillatory ventilation (HFOV) is used to improve oxygenation in PPHN cases. This study aimed to evaluate the hemodynamic changes in neonates with PPH on HFOV compared to conventional mechanical ventilation (CMV) using electrical cardiometry (EC).</p> Methods <p>This prospective cohort study included 58 full-term neonates with PPHN, admitted to a neonatal intensive care unit (NICU). Neonates were divided into two groups; group 1: those receiving CMV, and group 2: those switched to HFOV after CMV failure. Measurement of EC were taken at day 0, 1, 3, and 7 of MV.</p> Results <p>Cardiac output, index of contractility, and stroke volume were significantly lower in the HFOV group compared to the CMV at days 0, 1, 3, and 7. However, they significantly improved in both groups, but the improvement was less significant in the HFOV group. Systemic vascular resistance and thoracic fluid content were comparable between both groups at days 0, 1, 3, and 7.</p> Conclusions <p>Both HFOV and CMV improve the hemodynamic status in full-term neonates with PPHN. However, hemodynamic improvement was more obvious in the CMV group than in the HFOV group. Hence, HFOV should be used in PPHN only in severe cases.</p>

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Electrical cardiometry changes in full-term neonates with persistent pulmonary hypertension on high-frequency mechanical ventilation versus conventional mechanical ventilation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月1日

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  • Hassan Koura,
  • Doaa El Amrousy,
  • Noura Abdou,
  • Mostafa Awny,
  • Abdelrahman Elmashad

摘要

Background

Persistent pulmonary hypertension of the newborn (PPHN) is characterized by high pulmonary vascular resistance, causing right-to-left blood shunting and respiratory distress. High-frequency oscillatory ventilation (HFOV) is used to improve oxygenation in PPHN cases. This study aimed to evaluate the hemodynamic changes in neonates with PPH on HFOV compared to conventional mechanical ventilation (CMV) using electrical cardiometry (EC).

Methods

This prospective cohort study included 58 full-term neonates with PPHN, admitted to a neonatal intensive care unit (NICU). Neonates were divided into two groups; group 1: those receiving CMV, and group 2: those switched to HFOV after CMV failure. Measurement of EC were taken at day 0, 1, 3, and 7 of MV.

Results

Cardiac output, index of contractility, and stroke volume were significantly lower in the HFOV group compared to the CMV at days 0, 1, 3, and 7. However, they significantly improved in both groups, but the improvement was less significant in the HFOV group. Systemic vascular resistance and thoracic fluid content were comparable between both groups at days 0, 1, 3, and 7.

Conclusions

Both HFOV and CMV improve the hemodynamic status in full-term neonates with PPHN. However, hemodynamic improvement was more obvious in the CMV group than in the HFOV group. Hence, HFOV should be used in PPHN only in severe cases.