Introduction <p>Oral cancer (OC) is one of the major global health problems with a high incidence rate in developing countries. Early detection can improve the prognosis and survival rate of the disease.</p> Aim <p>The current study evaluates dentists’ general awareness, knowledge, attitude, and practice regarding oral cancer.</p> Methods <p>In the current cross-sectional study, a self-reported questionnaire was distributed to a sample of dentists in Egypt. A total of 700 dentists participated. The questionnaire included 27 questions on oral cancer knowledge, opinions, attitudes, and practices.</p> Results <p>The highest awareness of risk factors concentrated around tobacco and alcohol consumption, and the most acknowledged clinical presentations were non-healing ulcers, red lesions, white lesions, and induration. The tongue was considered a high-risk site by 69% of participants, followed by the floor of the mouth and the buccal/lip mucosa. Only 37% of the participants carried out proper clinical screening for OC, while only 31% carried out routine lymph node examinations. Sixty-six percent of participants considered themselves incompetent regarding detection of OC. Ninety-two percent of participants acknowledged the important role of dentists in the early detection of oral cancer, and 99% of them thought that oral cancer awareness campaigns are needed and would be effective. Awareness was significantly associated with years of practice.</p> Conclusion <p>Awareness regarding OC among the Egyptian dentists participating in the current survey showed definitive defects. Hence, efforts to raise awareness of OC among dental practitioners are an important factor in improving/early detection of OC, with the resultant increase in survival rate and decrease in morbidity. This can be reached only through more solid undergraduate syllabi and training as well as workshops and campaigns.</p>