Background <p>Depressive symptoms are frequently observed among individuals with schizophrenia and are linked to unfavorable clinical outcomes, including functional impairment and a higher likelihood of relapse. However, they are frequently underrecognized in routine clinical practice.</p> Aim <p>To determine the severity of depressive symptomatology and suicidal ideation in patients diagnosed with schizophrenia and to examine their association with the type of antipsychotic medication used.</p> Methods <p>This cross-sectional study included 92 patients with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Depressive symptoms were evaluated using the Hamilton Depression Rating Scale (HAM-D), and suicidal ideation was evaluated using Beck’s Scale for Suicide Ideation. Patients were categorized into two groups based on antipsychotic treatment used: typical and atypical.</p> Results <p>The mean HAM-D score was 6.9 ± 4.3, with 87% of patients exhibiting minimal to mild depressive symptoms. Suicidal ideation was present in 3.3% of patients. Patients receiving typical antipsychotics had significantly higher depression scores compared to those receiving atypical antipsychotics (median = 8 vs. 5, <i>p</i> = 0.002). Patients on atypical antipsychotics had a higher number of previous hospitalizations (<i>p</i> = 0.026). No significant associations were found between depressive symptoms and most sociodemographic variables, except for gender.</p> Conclusion <p>Depressive symptoms are common in patients with schizophrenia, even when predominantly mild. Patients receiving typical antipsychotics demonstrated higher HAM-D scores than those receiving atypical antipsychotics; however, the cross-sectional design precludes conclusions regarding temporal or causal relationships. The low prevalence of suicidal ideation limits conclusions regarding suicidality. Routine screening for depressive symptoms should be integrated into clinical care.</p>