Background <p>Skin disorders have a significant effect on psychological health, social functioning, and daily activities of patients, which in turn can severely impact their family caregivers’ quality of life.</p> Objectives <p>The goal of our study was to assess the prevalence of burnout in caregivers of patients with chronic skin diseases (vitiligo, psoriasis, and alopecia areata) and to examine its effect on their quality of life.</p> Methods <p>A cross-sectional study was carried out using self-assessment scales administered to 213 caregivers. The caregivers were equally divided among those caring for patients with vitiligo, alopecia areata, and psoriasis. We used the Zarit Burden Interview (ZBI) and the Family Dermatology Life Quality Index (FDLQI).</p> Results <p>It was found that 29.5% of caregivers reported “not having enough time” due to caregiving, especially those caring for patients with psoriasis and vitiligo. Additionally, 37.1% of caregivers experienced stress in balancing caregiving with other responsibilities, particularly those caring for patients with psoriasis and alopecia areata. The study also found that caregivers of psoriasis patients experienced the highest burden, followed by those of patients with vitiligo and alopecia areata. A positive association was found between ZBI scores and caregiver age, duration of patient care, FDLQI scores, and disease severity. Similarly, FDLQI scores correlated positively with caregiver age, time spent caregiving, duration, and disease severity.</p> Conclusion <p>Caregivers for patients with chronic skin illnesses face significant burdens which adversely affect quality of life. This study recognizes and addresses the challenges faced by these caregivers in order to provide better support systems and improve the quality of life for both caregivers and patients.</p>