Scholarlink

Background <p>Tobacco use disorder remains one of the most prevalent substances use disorders globally, contributing significantly to morbidity and mortality. While pharmacological and behavioral interventions have been effective, relapse rates remain high, necessitating the exploration of novel therapeutic approaches. One such approach is repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique that has shown promise in various neuropsychiatric disorders, including medication-resistant conditions.</p> Objective <p>To evaluate the efficacy of rTMS in smoking cessation, its impact on abstinence rates, nicotine dependence, and craving.</p> Methods <p>We conducted a comprehensive search across multiple databases (PubMed, Scopus, Web of Science, Cochrane, PsycINFO, and Clinicaltrials.gov) from inception to August 2024. Eligible studies were randomized controlled trials (RCTs) evaluating rTMS as a treatment for smoking cessation, with outcomes including nicotine dependence, craving, abstinence, and cigarette consumption.</p> Results <p>We included 17 RCTs involving 859 participants were included in this review. The pooled analysis revealed a statistically insignificant reduction in nicotine dependence based on the Fagerström Test (MD = -0.40, 95% CI [-1.16 to 0.35], <i>P</i> = 0.30). rTMS demonstrated significant reductions in craving, as measured by the Tobacco Questionnaire for Smoking Urges (MD = -10.89, 95% CI [-12.94 to -8.85], <i>P</i> &lt; 0.00001). Self-reported abstinence showed a significant improvement (RR = 1.89, 95% CI [1.12 to 3.19], <i>P</i> = 0.02). However, no significant effects were observed for self-reported cigarette consumption (MD = -2.74, 95% CI [-7.26 to 1.79], <i>P</i> = 0.24) or the Visual Analog Scale for craving (SMD = -0.29, 95% CI [-0.67 to 0.10], <i>P</i> = 0.14).</p> Conclusion <p>rTMS shows promising potential as an adjunctive treatment for smoking cessation by reducing nicotine dependence (to some extent) and improving abstinence rates. However, its effectiveness is not uniform across all smoking-related outcomes. With further research, rTMS could become a valuable component of comprehensive smoking cessation strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Efficacy of repetitive transcranial magnetic stimulation for smoking cessation: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月29日

查看全文
  • Youssef A. Ismail,
  • Omar K. Habib,
  • Yahya El-Banan,
  • Raneem Ramadan,
  • Mohamed O. Henidak,
  • Mohamed E. El-Badry,
  • Ahmed R. Rabea,
  • Amira A. Fouad,
  • Salsapeel I. El-Tahlawy,
  • Rahma M. El-Shawa,
  • Mohamed Atef,
  • Rahma A. Abd El-Kader,
  • Abdullah El-Lawendy,
  • Mariam El-Morsy,
  • Mariam S. El-Rayes,
  • Hanem El-Hasanen,
  • Moaz Abouelmagd

摘要

Background

Tobacco use disorder remains one of the most prevalent substances use disorders globally, contributing significantly to morbidity and mortality. While pharmacological and behavioral interventions have been effective, relapse rates remain high, necessitating the exploration of novel therapeutic approaches. One such approach is repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique that has shown promise in various neuropsychiatric disorders, including medication-resistant conditions.

Objective

To evaluate the efficacy of rTMS in smoking cessation, its impact on abstinence rates, nicotine dependence, and craving.

Methods

We conducted a comprehensive search across multiple databases (PubMed, Scopus, Web of Science, Cochrane, PsycINFO, and Clinicaltrials.gov) from inception to August 2024. Eligible studies were randomized controlled trials (RCTs) evaluating rTMS as a treatment for smoking cessation, with outcomes including nicotine dependence, craving, abstinence, and cigarette consumption.

Results

We included 17 RCTs involving 859 participants were included in this review. The pooled analysis revealed a statistically insignificant reduction in nicotine dependence based on the Fagerström Test (MD = -0.40, 95% CI [-1.16 to 0.35], P = 0.30). rTMS demonstrated significant reductions in craving, as measured by the Tobacco Questionnaire for Smoking Urges (MD = -10.89, 95% CI [-12.94 to -8.85], P < 0.00001). Self-reported abstinence showed a significant improvement (RR = 1.89, 95% CI [1.12 to 3.19], P = 0.02). However, no significant effects were observed for self-reported cigarette consumption (MD = -2.74, 95% CI [-7.26 to 1.79], P = 0.24) or the Visual Analog Scale for craving (SMD = -0.29, 95% CI [-0.67 to 0.10], P = 0.14).

Conclusion

rTMS shows promising potential as an adjunctive treatment for smoking cessation by reducing nicotine dependence (to some extent) and improving abstinence rates. However, its effectiveness is not uniform across all smoking-related outcomes. With further research, rTMS could become a valuable component of comprehensive smoking cessation strategies.