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Background <p>Tobacco use disorder (TUD) is a long-term condition marked by compulsive smoking, intense cravings, and withdrawal effects. Repetitive transcranial magnetic stimulation (r-TMS), which targets the left dorsolateral prefrontal cortex (DLPFC), has been identified as a promising therapeutic approach. However, research on the use of r-TMS for treating TUD in Egypt remains scarce. This study aimed to assess the effectiveness of active r-TMS in reducing smoking behavior, withdrawal symptoms, cravings, and nicotine dependence, in comparison to sham treatment, while also examining its tolerability as a treatment option for TUD.</p> Results <p>Forty male smokers (aged 18–60 years) who smoked a minimum of 10 cigarettes per day for a minimum of 12 months were randomized into two groups: the active r-TMS group (<i>n</i> = 20) and the sham group (<i>n</i> = 20). Active r-TMS treatment, delivered over 15 sessions (5 sessions weekly for 3 consecutive weeks), significantly reduced the number of cigarettes smoked daily (<i>p</i> = 0.001), nicotine dependence (<i>p</i> = 0.023), withdrawal symptoms (both self-reported and observer-rated) (<i>p</i> = 0.001), and craving (<i>p</i> = 0.007) compared to the sham treatment. Urinary cotinine levels, a biomarker of nicotine intake, were also significantly lower in the active r-TMS group during the follow-up period (<i>p</i> = 0.011). The treatment was generally well-tolerated, with only minor side effects, such as headaches (22.5%).</p> Conclusions <p>Active r-TMS targeting the left DLPFC effectively reduced nicotine dependence, withdrawal symptoms, and craving, demonstrating its potential as a promising treatment for TUD. These findings align with previous studies supporting the efficacy of r-TMS in addiction treatment. Further research is needed to optimize treatment protocols, explore combined therapies, and assess long-term outcomes to improve smoking cessation in diverse&#xa0;populations.</p>

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Efficacy and safety of repetitive transcranial magnetic stimulation in the treatment of male smokers with tobacco use disorder: a randomized controlled trial

  • 期刊论文

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  • 发表日期：

    2025年2月4日

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  • Salma W. Mousa,
  • Adel A. Badawy,
  • Gehan F. Attia,
  • Wesam A. Ghareeb

摘要

Background

Tobacco use disorder (TUD) is a long-term condition marked by compulsive smoking, intense cravings, and withdrawal effects. Repetitive transcranial magnetic stimulation (r-TMS), which targets the left dorsolateral prefrontal cortex (DLPFC), has been identified as a promising therapeutic approach. However, research on the use of r-TMS for treating TUD in Egypt remains scarce. This study aimed to assess the effectiveness of active r-TMS in reducing smoking behavior, withdrawal symptoms, cravings, and nicotine dependence, in comparison to sham treatment, while also examining its tolerability as a treatment option for TUD.

Results

Forty male smokers (aged 18–60 years) who smoked a minimum of 10 cigarettes per day for a minimum of 12 months were randomized into two groups: the active r-TMS group (n = 20) and the sham group (n = 20). Active r-TMS treatment, delivered over 15 sessions (5 sessions weekly for 3 consecutive weeks), significantly reduced the number of cigarettes smoked daily (p = 0.001), nicotine dependence (p = 0.023), withdrawal symptoms (both self-reported and observer-rated) (p = 0.001), and craving (p = 0.007) compared to the sham treatment. Urinary cotinine levels, a biomarker of nicotine intake, were also significantly lower in the active r-TMS group during the follow-up period (p = 0.011). The treatment was generally well-tolerated, with only minor side effects, such as headaches (22.5%).

Conclusions

Active r-TMS targeting the left DLPFC effectively reduced nicotine dependence, withdrawal symptoms, and craving, demonstrating its potential as a promising treatment for TUD. These findings align with previous studies supporting the efficacy of r-TMS in addiction treatment. Further research is needed to optimize treatment protocols, explore combined therapies, and assess long-term outcomes to improve smoking cessation in diverse populations.