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Background <p>Hypertension (HTN) remains a major global health problem, and inadequate blood pressure (BP) control contributes substantially to cardiovascular risk. The endothelial activation and stress index (EASIX), derived from routine laboratory parameters, has been proposed as a marker of vascular stress. Existing studies in hypertensive populations relied on office BP measurements and included patients with multiple comorbidities. This study evaluated the association between EASIX and 24-h ambulatory BP monitoring (ABPM) in a homogeneous cohort with isolated primary HTN.</p> Methods <p>This retrospective cross-sectional study included 192 adults aged 18–70&#xa0;years diagnosed with HTN and undergoing 24-h ABPM. Patients were categorized into <i>controlled</i> and <i>uncontrolled</i> BP groups according to 24-h, daytime, and nighttime ABPM thresholds defined by the 2024 European Society of Cardiology guideline. The EASIX score was calculated as [lactate dehydrogenase × creatinine]/platelets and log<sub>2</sub>-transformed for analysis. Group comparisons, correlation analyses, multivariable logistic regression, and ROC analyses were performed.</p> Results <p>The EASIX score was significantly higher in the uncontrolled BP group than in the controlled BP group. Logistic regression identified ascending aortic diameter, serum sodium, serum albumin, and log<sub>2</sub> (EASIX) as independent factors associated with BP control status. EASIX demonstrated good discriminative performance in identifying hypertensive patients with inadequate BP control on 24-h ABPM.</p> Conclusions <p>EASIX demonstrated good discriminative performance for identifying hypertensive patients with inadequate BP control on ABPM. These findings suggest its potential role in risk stratification, warranting validation in prospective studies.</p> Graphical Abstract <p></p>

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The role of the EASIX score in patients with hypertension: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月24日

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  • Ender Murat,
  • Mehmet Sadık Karpat,
  • Yusuf Öztürk,
  • Hatice Taşkan,
  • Ozan Köksal,
  • Ayşe Saatcı Yaşar,
  • Arslan Öcal,
  • Serkan Asil,
  • Salim Yaşar,
  • Murat Çelik,
  • Uygar Çağdaş Yüksel,
  • Cem Barçın

摘要

Background

Hypertension (HTN) remains a major global health problem, and inadequate blood pressure (BP) control contributes substantially to cardiovascular risk. The endothelial activation and stress index (EASIX), derived from routine laboratory parameters, has been proposed as a marker of vascular stress. Existing studies in hypertensive populations relied on office BP measurements and included patients with multiple comorbidities. This study evaluated the association between EASIX and 24-h ambulatory BP monitoring (ABPM) in a homogeneous cohort with isolated primary HTN.

Methods

This retrospective cross-sectional study included 192 adults aged 18–70 years diagnosed with HTN and undergoing 24-h ABPM. Patients were categorized into controlled and uncontrolled BP groups according to 24-h, daytime, and nighttime ABPM thresholds defined by the 2024 European Society of Cardiology guideline. The EASIX score was calculated as [lactate dehydrogenase × creatinine]/platelets and log2-transformed for analysis. Group comparisons, correlation analyses, multivariable logistic regression, and ROC analyses were performed.

Results

The EASIX score was significantly higher in the uncontrolled BP group than in the controlled BP group. Logistic regression identified ascending aortic diameter, serum sodium, serum albumin, and log2 (EASIX) as independent factors associated with BP control status. EASIX demonstrated good discriminative performance in identifying hypertensive patients with inadequate BP control on 24-h ABPM.

Conclusions

EASIX demonstrated good discriminative performance for identifying hypertensive patients with inadequate BP control on ABPM. These findings suggest its potential role in risk stratification, warranting validation in prospective studies.

Graphical Abstract