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<p>Uterine fibroids are commonly benign but significantly impact women’s health due to undiagnosed asymptomatic progression and lack of awareness. While hysterectomy and myomectomy remain the primary treatments for uterine fibroids, patients need non-surgical alternatives in overall fibroid management. Modern scientific methods such as Artificial Intelligence (AI)-driven diagnostics combined with ancient healing techniques can provide alternative curing methods for affected patients. In this review, we have highlighted three key non-surgical approaches along with molecular basis of uterine fibroid development for futuristic personalized therapies. The non-surgical methods include (i) AI driven diagnostics using 3D Super-Resolution Diffusion-Weighted Imaging (SR-DWI) and support vector machines (SVMs), (ii) Phytochemical-based therapeutics such as curcumin (<i>Curcuma longa</i>), resveratrol (<i>Vitis vinifera</i>), and epigallocatechin gallate (EGCG, <i>Camellia sinensis</i>), (iii) Physical therapies like Yoga and acupuncture. Advanced imaging techniques improve diagnostic accuracy which allows timely intervention. Phytochemicals regulate fibrotic pathways, while yoga and acupuncture alleviate stress and support uterine health, providing a comprehensive non-surgical treatment approach. Additionally, we also describe the molecular basis for uterine fibroid development in terms of germline mutations, epigenetics and signalling pathways which are well correlated with our proposed phytochemical and physical therapies. Overall, we emphasize that the AI driven diagnostics combined with ancient therapeutic approaches offer an adjunctive strategy for effective fibroid management thereby potentially reducing the need for hysterectomy.</p>

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Artificial intelligence driven based diagnostics with combined surgical and non-surgical management of uterine fibroids: a narrative review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月2日

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  • Manshi Kumari Gupta,
  • Sukanya Pattnaik,
  • C. Sudandiradoss

摘要

Uterine fibroids are commonly benign but significantly impact women’s health due to undiagnosed asymptomatic progression and lack of awareness. While hysterectomy and myomectomy remain the primary treatments for uterine fibroids, patients need non-surgical alternatives in overall fibroid management. Modern scientific methods such as Artificial Intelligence (AI)-driven diagnostics combined with ancient healing techniques can provide alternative curing methods for affected patients. In this review, we have highlighted three key non-surgical approaches along with molecular basis of uterine fibroid development for futuristic personalized therapies. The non-surgical methods include (i) AI driven diagnostics using 3D Super-Resolution Diffusion-Weighted Imaging (SR-DWI) and support vector machines (SVMs), (ii) Phytochemical-based therapeutics such as curcumin (Curcuma longa), resveratrol (Vitis vinifera), and epigallocatechin gallate (EGCG, Camellia sinensis), (iii) Physical therapies like Yoga and acupuncture. Advanced imaging techniques improve diagnostic accuracy which allows timely intervention. Phytochemicals regulate fibrotic pathways, while yoga and acupuncture alleviate stress and support uterine health, providing a comprehensive non-surgical treatment approach. Additionally, we also describe the molecular basis for uterine fibroid development in terms of germline mutations, epigenetics and signalling pathways which are well correlated with our proposed phytochemical and physical therapies. Overall, we emphasize that the AI driven diagnostics combined with ancient therapeutic approaches offer an adjunctive strategy for effective fibroid management thereby potentially reducing the need for hysterectomy.