Scholarlink

Background <p>Currently, the optimal method of ovarian stimulation (OS) for in-vitro fertilization (IVF) in the patients with polycystic ovarian syndrome (PCOS) is unknown. The present research aims to study the efficacy of High-OS method for treating infertile patients with PCOS and to compare it with a low-OS protocol.</p> Methods <p>The study was an open label, randomized, parallel treatment clinical trial comparing a high stimulatory gonadotropin dose (group A) to low stimulatory dose (group B) in PCOS infertile women undergoing ICSI cycle for infertility management in El Madina fertility Center between December 2023 and March 2025. IVF outcomes of two groups were analyzed statistically.</p> Results <p>The statistical analysis showed that group A of high stimulation dose had a shorter stimulation duration (<i>P</i> = 0.025) and numerically higher numbers of retrieved oocytes, MII oocytes, embryos formed, and numerically higher clinical pregnancy rates without reaching statistical significance than group B of low stimulation dose. High-OS protocol showed numerically higher fertilization and clinical pregnancy rates without an increased risk of OHSS.</p> Conclusions <p>High-OS with r-FSH may be a beneficial method of controlled ovarian stimulation (COS) in non-obese infertile women with PCOS in respect to total dose of prescribed gonadotropin, the optimal number of retrieved oocytes and embryos obtained, fertilization rate and clinical pregnancy rate without increased risk of OHSS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative evaluation of High- vs. Low-Ovarian stimulation doses in PCOS patients: impact on ICSI outcomes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月12日

查看全文
  • Hesham Ahmed Kadry,
  • Mohamed El Mahdy,
  • Omar Zakaria,
  • Haneen Mohamed,
  • Ashraf Abo Ali

摘要

Background

Currently, the optimal method of ovarian stimulation (OS) for in-vitro fertilization (IVF) in the patients with polycystic ovarian syndrome (PCOS) is unknown. The present research aims to study the efficacy of High-OS method for treating infertile patients with PCOS and to compare it with a low-OS protocol.

Methods

The study was an open label, randomized, parallel treatment clinical trial comparing a high stimulatory gonadotropin dose (group A) to low stimulatory dose (group B) in PCOS infertile women undergoing ICSI cycle for infertility management in El Madina fertility Center between December 2023 and March 2025. IVF outcomes of two groups were analyzed statistically.

Results

The statistical analysis showed that group A of high stimulation dose had a shorter stimulation duration (P = 0.025) and numerically higher numbers of retrieved oocytes, MII oocytes, embryos formed, and numerically higher clinical pregnancy rates without reaching statistical significance than group B of low stimulation dose. High-OS protocol showed numerically higher fertilization and clinical pregnancy rates without an increased risk of OHSS.

Conclusions

High-OS with r-FSH may be a beneficial method of controlled ovarian stimulation (COS) in non-obese infertile women with PCOS in respect to total dose of prescribed gonadotropin, the optimal number of retrieved oocytes and embryos obtained, fertilization rate and clinical pregnancy rate without increased risk of OHSS.