Scholarlink

Objectives <p>Impacted wisdom teeth are a common dental issue, often associated with pain and complications requiring surgical intervention. Genetic factors contributing to this condition remain poorly understood. This study investigates the association of the Bone Morphogenetic Protein 2 (<i>BMP2</i>) rs3178250 genetic variant with impacted wisdom teeth.</p> Methods <p>We conducted a case-control study involving 140 participants, including 70 people with impacted wisdom teeth and 70 healthy controls. Genotyping of the <i>BMP2</i> rs3178250 variant was performed via polymerase chain reaction (PCR) in combination with restriction fragment length polymorphism (RFLP). Statistical analyses were employed to assess the association between the variant and impacted teeth.</p> Results <p>Our findings indicate a significant correlation between the <i>BMP2</i> rs3178250 variant and the risk of impacted wisdom teeth. The codominant 1 TC vs. TT (OR = 0.41; 95% CI 0.25–0.89; <i>p</i> = 0.011) and dominant TC + CC vs. TT (OR = 0.39; 95% CI 0.20–0.75; <i>p</i> = 0.006) models of inheritance reduced impacted wisdom teeth risk by 59 and 61%, respectively. Additionally, the C allele of rs3178250 (OR = 0.52; 95% CI 0.33–0.89; <i>p</i> = 0.009) decreased the risk of impacted wisdom teeth by 48%.</p> Conclusion <p>Suggesting that this genetic factor may contribute to the condition’s pathophysiology. These insights enhance our understanding of the genetic predisposition to dental impaction and pave the way for further research into targeted therapeutic strategies and preventive measures. <i>BMP2</i> rs3178250 variant were associated with Impacted wisdom teeth risk in our population. Larger sample sizes will be necessary to confirm these findings and investigate other potential causal factors involved in Impacted wisdom teeth etiology.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Unraveling the role of BMP2 variant in impacted wisdom teeth: insights from a case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月25日

查看全文
  • Mahboobeh Sabeti Akbar-Abad,
  • Mahdi Majidpour,
  • Shoeib Mohamadifard,
  • Reza Khammari,
  • Hossein Shahriari,
  • Yegane Piroozan,
  • Sirous Risbaf Fakour,
  • Ebrahim Alijani

摘要

Objectives

Impacted wisdom teeth are a common dental issue, often associated with pain and complications requiring surgical intervention. Genetic factors contributing to this condition remain poorly understood. This study investigates the association of the Bone Morphogenetic Protein 2 (BMP2) rs3178250 genetic variant with impacted wisdom teeth.

Methods

We conducted a case-control study involving 140 participants, including 70 people with impacted wisdom teeth and 70 healthy controls. Genotyping of the BMP2 rs3178250 variant was performed via polymerase chain reaction (PCR) in combination with restriction fragment length polymorphism (RFLP). Statistical analyses were employed to assess the association between the variant and impacted teeth.

Results

Our findings indicate a significant correlation between the BMP2 rs3178250 variant and the risk of impacted wisdom teeth. The codominant 1 TC vs. TT (OR = 0.41; 95% CI 0.25–0.89; p = 0.011) and dominant TC + CC vs. TT (OR = 0.39; 95% CI 0.20–0.75; p = 0.006) models of inheritance reduced impacted wisdom teeth risk by 59 and 61%, respectively. Additionally, the C allele of rs3178250 (OR = 0.52; 95% CI 0.33–0.89; p = 0.009) decreased the risk of impacted wisdom teeth by 48%.

Conclusion

Suggesting that this genetic factor may contribute to the condition’s pathophysiology. These insights enhance our understanding of the genetic predisposition to dental impaction and pave the way for further research into targeted therapeutic strategies and preventive measures. BMP2 rs3178250 variant were associated with Impacted wisdom teeth risk in our population. Larger sample sizes will be necessary to confirm these findings and investigate other potential causal factors involved in Impacted wisdom teeth etiology.