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Background <p>Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with the characteristics of demyelination and axonal degeneration at a young age. Genetic factors may play an important role in the development of multiple sclerosis. Interleukin 10 (IL-10) is a homodimer anti-inflammatory cytokine. So far, there has been no research on the relationship between the − 1082 (G/A) polymorphism of this gene and the aforementioned disease in a large statistical population and with definitive results. The purpose of this study is to investigate the relationship between the 1082-(G/A) polymorphism in interleukin 10 and the genetic predisposition to MS and the onset of the disease in patients.</p> Method <p>Databases including Google Scholar, PubMed, Scopus and Web of Science were searched to find research on the association between polymorphism − 1082 (G/A) interleukin 10 gene and MS disease. Also, the studies include reporting the genotype frequency between the two experimental and control groups and studies that have sufficient information and genetic distribution to estimate the odds ratio (OR) with a confidence interval (CI) of 95%.</p> Results <p>In total, research was conducted on 1042 subjects and 1299 control subjects. Polymorphism − 1082 (rs1800896) (G/A) of interleukin 10 gene was analyzed. This meta-analysis provides a consolidated examination of the association between the IL-10 -1082 G/A polymorphism and MS by synthesizing data across a broader and more diverse population than previously reported.</p> Conclusion <p>Our findings showed that there is significant relationship between genotypes of polymorphism − 1082 (rs1800896) (G/A) of interleukin 10 gene and MS disease.</p>

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Interleukin 10 gene polymorphism − 1082 (rs1800896) and its effect in multiple sclerosis

  • 期刊论文

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  • 发表日期：

    2026年2月1日

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  • Massod Khorasani,
  • Akram Nezafati,
  • Elaheh Rezaei,
  • Milad Khorasani,
  • Saeed khosroabadi

摘要

Background

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system with the characteristics of demyelination and axonal degeneration at a young age. Genetic factors may play an important role in the development of multiple sclerosis. Interleukin 10 (IL-10) is a homodimer anti-inflammatory cytokine. So far, there has been no research on the relationship between the − 1082 (G/A) polymorphism of this gene and the aforementioned disease in a large statistical population and with definitive results. The purpose of this study is to investigate the relationship between the 1082-(G/A) polymorphism in interleukin 10 and the genetic predisposition to MS and the onset of the disease in patients.

Method

Databases including Google Scholar, PubMed, Scopus and Web of Science were searched to find research on the association between polymorphism − 1082 (G/A) interleukin 10 gene and MS disease. Also, the studies include reporting the genotype frequency between the two experimental and control groups and studies that have sufficient information and genetic distribution to estimate the odds ratio (OR) with a confidence interval (CI) of 95%.

Results

In total, research was conducted on 1042 subjects and 1299 control subjects. Polymorphism − 1082 (rs1800896) (G/A) of interleukin 10 gene was analyzed. This meta-analysis provides a consolidated examination of the association between the IL-10 -1082 G/A polymorphism and MS by synthesizing data across a broader and more diverse population than previously reported.

Conclusion

Our findings showed that there is significant relationship between genotypes of polymorphism − 1082 (rs1800896) (G/A) of interleukin 10 gene and MS disease.