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Background <p>Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients.</p> Methods <p>We examined the genes <i>IL17A</i> and <i>IL17F</i> in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the <i>IL17A</i> gene, and 116 RA patients and 107 healthy individuals for the <i>IL17F</i> gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses.</p> Results <p>There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P =  &lt; 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780).</p> Conclusion <p>Based on this study, rs2275913 polymorphism of gene <i>IL17A</i> could contribute to the risk of rheumatoid arthritis in Iranian patients.</p>

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Association of IL-17A gene polymorphism rs2275913 with rheumatoid arthritis susceptibility in Iranian patients

  • 期刊论文

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  • 发表日期：

    2025年7月31日

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  • Mozhgan Khojasteh,
  • Reza Mansori,
  • Ali Dehghani,
  • Mehdi Mahmoudi,
  • Saed Mazazarzadeh,
  • Emad Babakhanzadeh

摘要

Background

Rheumatoid arthritis (RA) is a long-term autoimmune disease causing chronic progressive inflammatory disease. In this study, we aimed to evaluate a new strategy for gene polymorphism of IL17A which may be related to the risk of rheumatoid arthritis in Iranian patients.

Methods

We examined the genes IL17A and IL17F in relation to RA. They compared the DNA of 100 RA patients and 92 healthy individuals for the IL17A gene, and 116 RA patients and 107 healthy individuals for the IL17F gene. A technique called PCR–RFLP was used to analyze their genetic makeup. SPSS software was used for statistical analyses.

Results

There was a significant association between the patients and control group in rs2275913 (OR = 2.97, 95%CI = 1.38–6.46, P =  < 0.001). However, there was no significant relationship between the patient and control group at rs763780 (OR = 1.49, 95%CI = 0.806–2.76, P = 0.201). Also, in this study, the association between genotypes mentioned above and Anti-ccp was investigated. There was no significant correlation between any genotype and positive Anti-ccp. (P = 0.142 for rs2275913 and P = 0.330 for rs763780).

Conclusion

Based on this study, rs2275913 polymorphism of gene IL17A could contribute to the risk of rheumatoid arthritis in Iranian patients.