Scholarlink

<p>Type 2 diabetes (T2D) is a significant public health concern in Malaysia, with rising prevalence across its multi-ethnic population. Genetic predisposition plays a key role in the development of T2D, but studies focusing on Malaysian populations remain limited. This review summarizes existing evidence on genetic variants associated with T2D in the Malaysian population, focusing on single-nucleotide variants and ethnic-specific risk patterns. A comprehensive literature search was conducted across major databases, identifying 31 relevant studies published between 2000 and 2024. Key findings were discussed to identify commonly implicated variants and ethnic differences in the association with T2D. These findings highlight the ethnic-specific genetic risk factors within the Malaysians, confirming the need to consider ethnic diversity and inclusion in T2D genetic study design, analysis, and clinical translation. This review offers a novel insight into the ethnic-specific effects of Malaysian T2D risks, particularly the underrepresented Malay ethnic group, which is important for the future development of precision medicine strategies for T2D in Malaysia. </p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Genetics of type 2 diabetes (T2D) in Malaysia: a review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月21日

查看全文
  • Nurul Humaira Mohd Redzuan,
  • Siti Aishah Sulaiman,
  • Nor Azian Abdul Murad,
  • Norfazilah Ahmad,
  • Chim C. Lang,
  • Rahman Jamal

摘要

Type 2 diabetes (T2D) is a significant public health concern in Malaysia, with rising prevalence across its multi-ethnic population. Genetic predisposition plays a key role in the development of T2D, but studies focusing on Malaysian populations remain limited. This review summarizes existing evidence on genetic variants associated with T2D in the Malaysian population, focusing on single-nucleotide variants and ethnic-specific risk patterns. A comprehensive literature search was conducted across major databases, identifying 31 relevant studies published between 2000 and 2024. Key findings were discussed to identify commonly implicated variants and ethnic differences in the association with T2D. These findings highlight the ethnic-specific genetic risk factors within the Malaysians, confirming the need to consider ethnic diversity and inclusion in T2D genetic study design, analysis, and clinical translation. This review offers a novel insight into the ethnic-specific effects of Malaysian T2D risks, particularly the underrepresented Malay ethnic group, which is important for the future development of precision medicine strategies for T2D in Malaysia.