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Background <p>Iron deficiency is a cause of anemia in pregnant women. Iron metabolism is closely related to zinc levels and the state of zinc-containing proteins. Zinc-binding proteins (<i>ZNFs</i>) can also bind other metal ions. Genetic factors can also be a factor leading to unstable iron levels in the blood.</p> Results <p>The aim of this study was to investigate the relationship between rs259983 of the zinc finger protein 831 (<i>ZNF831</i>) gene and anemia in pregnant women with gestational diabetes mellitus (GDM). The PCR test system with Taq-Man samples was developed for genotyping rs259983 of the <i>ZNF831</i> gene. As a result, an association was found between rs259983 of the <i>ZNF831</i> gene and the risk of anemia. According to in silico analysis, the <i>ZNF831</i> protein is able to bind iron (FE, 0.69) and other ions, which may play an essential role in anemia pathogenesis.</p> Conclusions <p>Carriers of the C allele in the homozygous state rs259983 of the <i>ZNF831</i> are at greater risk of developing anemia. Further studies are required to assess the effect of <i>ZNF831</i> polymorphisms on the risk of pregnancy pathologies.</p>

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Polymorphism rs259983 of the ZNF831 gene is associated with the risk of anemia in pregnant women with gestational diabetes

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  • 发表日期：

    2025年6月3日

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  • Nataliia Karpova,
  • Olga Dmitrenko,
  • Ekaterina Arshinova,
  • Malik Nurbekov

摘要

Background

Iron deficiency is a cause of anemia in pregnant women. Iron metabolism is closely related to zinc levels and the state of zinc-containing proteins. Zinc-binding proteins (ZNFs) can also bind other metal ions. Genetic factors can also be a factor leading to unstable iron levels in the blood.

Results

The aim of this study was to investigate the relationship between rs259983 of the zinc finger protein 831 (ZNF831) gene and anemia in pregnant women with gestational diabetes mellitus (GDM). The PCR test system with Taq-Man samples was developed for genotyping rs259983 of the ZNF831 gene. As a result, an association was found between rs259983 of the ZNF831 gene and the risk of anemia. According to in silico analysis, the ZNF831 protein is able to bind iron (FE, 0.69) and other ions, which may play an essential role in anemia pathogenesis.

Conclusions

Carriers of the C allele in the homozygous state rs259983 of the ZNF831 are at greater risk of developing anemia. Further studies are required to assess the effect of ZNF831 polymorphisms on the risk of pregnancy pathologies.