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<p><i>Clanis bilineata tsingtauica</i> is nutrient-rich, containing proteins, amino acids, fatty acids and minerals. However, its nutritional efficacy and safety in mammals remain unclear. This study aimed to assess food utilization, allergy responses, and correlative indices in male and female mice after dietary inclusion of varying doses of <i>C. bilineata tsingtauica</i> larval powder (CLP). The results indicate that low-dose CLP significantly reduced daily food intake in female mice by 10.3%. CLP supplementation ensured weight gain in mice, while their food conversion ratio improved by at least 3.2%. No allergic behavior or mortality was observed in the mice, and there were no significant changes in organ weights. Additionally, CLP did not significantly affect the thickness of the dermis and epidermis in the dorsal region of the male mice; however, the mast cell density of male mice in the high-dose CLP group increased significantly by 1.1 times. In the CLP-treated group, male mice exhibited a 1.3-fold increase in IgM levels, accompanied by a 30.2% decrease in IgG and a 28.1% decrease in IgE levels; intestinal <i>Tnf</i> expression was significantly upregulated by 1.4-fold. CLP-treated female mice exhibited significantly elevated IgM and histamine levels, increasing by 1.3-fold and 1.2-fold, respectively; in the medium-dose group, IgG and IgE levels decreased significantly by 16.2% and 12.1%, respectively. Strongly correlated indicators include CLP dose and <i>Tnf</i> expression in male mice, and food conversion ratio and histamine content in female mice, among others. In conclusion, CLP is a safe dietary supplement with low allergenic potential in mice, offering a theoretical foundation for the development and safety assessment of food products derived from this larva.</p> Graphical Abstract <p></p>

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Effect of Clanis bilineata tsingtauica larval powder supplementation on the food utilization and allergenicity in mice

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月2日

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  • Zong-Nan Li,
  • Lei Qian,
  • Qing-Yi Li,
  • Yi Qin,
  • Yuan-Yuan Huang,
  • Rong-Hai He,
  • Ran-Ran Tang,
  • Huai-Jian Liao

摘要

Clanis bilineata tsingtauica is nutrient-rich, containing proteins, amino acids, fatty acids and minerals. However, its nutritional efficacy and safety in mammals remain unclear. This study aimed to assess food utilization, allergy responses, and correlative indices in male and female mice after dietary inclusion of varying doses of C. bilineata tsingtauica larval powder (CLP). The results indicate that low-dose CLP significantly reduced daily food intake in female mice by 10.3%. CLP supplementation ensured weight gain in mice, while their food conversion ratio improved by at least 3.2%. No allergic behavior or mortality was observed in the mice, and there were no significant changes in organ weights. Additionally, CLP did not significantly affect the thickness of the dermis and epidermis in the dorsal region of the male mice; however, the mast cell density of male mice in the high-dose CLP group increased significantly by 1.1 times. In the CLP-treated group, male mice exhibited a 1.3-fold increase in IgM levels, accompanied by a 30.2% decrease in IgG and a 28.1% decrease in IgE levels; intestinal Tnf expression was significantly upregulated by 1.4-fold. CLP-treated female mice exhibited significantly elevated IgM and histamine levels, increasing by 1.3-fold and 1.2-fold, respectively; in the medium-dose group, IgG and IgE levels decreased significantly by 16.2% and 12.1%, respectively. Strongly correlated indicators include CLP dose and Tnf expression in male mice, and food conversion ratio and histamine content in female mice, among others. In conclusion, CLP is a safe dietary supplement with low allergenic potential in mice, offering a theoretical foundation for the development and safety assessment of food products derived from this larva.

Graphical Abstract