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<p>The ideal wound care materials for wilderness first aid should be convenient for storage, easy to use, adhesive, antibacterial, anti-inflammatory, pro-angiogenic, wound-closure promoting, and simple for clinical translation. To meet all requirements, we developed a supramolecular FPC hydrogel by simply co-assembling 2-amino-2′-fluoro-2′-deoxyadenosine (FA), polydeoxyribonucleotide (PDRN), and collagen III (COL-III)-fully active pharmaceutical ingredients. Based on the abundant hydrogen bonding interactions among FA, PDRN, and COL-III, this hydrogel exhibited sprayability, tissue adhesiveness, and superior biological performance. In vivo studies showed that due to synergistic effects among FA, PDRN, and COL-III, FPC hydrogels offered significant anti-inflammatory benefits and angiogenic capabilities, which promoted granulation tissue formation, collagen deposition, wound tissue epithelialization, and effectively sped up wound healing. Furthermore, the FPC hydrogel could be conveniently stored in a bottle and sterilized through boiling, making it well-suited for wilderness first aid applications. This hydrogel has the potential to transform wound care by offering a versatile solution for both outdoor and everyday wound management needs.</p> Graphical Abstract <p></p>

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Sprayable supramolecular hydrogel with minimalism for wilderness first aid: integration of mechanical performance and biofunctionality

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月30日

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  • Xiaoming Li,
  • Siqi Liu,
  • Jiahui Zhou,
  • Jiyang Li,
  • Shuo Yang,
  • Jimin Guo,
  • Jianjun Zhang

摘要

The ideal wound care materials for wilderness first aid should be convenient for storage, easy to use, adhesive, antibacterial, anti-inflammatory, pro-angiogenic, wound-closure promoting, and simple for clinical translation. To meet all requirements, we developed a supramolecular FPC hydrogel by simply co-assembling 2-amino-2′-fluoro-2′-deoxyadenosine (FA), polydeoxyribonucleotide (PDRN), and collagen III (COL-III)-fully active pharmaceutical ingredients. Based on the abundant hydrogen bonding interactions among FA, PDRN, and COL-III, this hydrogel exhibited sprayability, tissue adhesiveness, and superior biological performance. In vivo studies showed that due to synergistic effects among FA, PDRN, and COL-III, FPC hydrogels offered significant anti-inflammatory benefits and angiogenic capabilities, which promoted granulation tissue formation, collagen deposition, wound tissue epithelialization, and effectively sped up wound healing. Furthermore, the FPC hydrogel could be conveniently stored in a bottle and sterilized through boiling, making it well-suited for wilderness first aid applications. This hydrogel has the potential to transform wound care by offering a versatile solution for both outdoor and everyday wound management needs.

Graphical Abstract