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<p>Konjac (<i>Amorphophallus konjac</i>) is an important food crop and a traditional medicinal herb in China. However, bacterial soft rot poses a serious threat to konjac production and quality. In this study, we identified <i>Pectobacterium aroidearum</i> as the causative pathogen of soft rot in konjac and investigated the antibacterial effects of kasugamycin (KSM) against this bacterium. Our results show that KSM exhibits strong antibacterial activity, significantly reducing the virulence of <i>P. aroidearum</i> and providing both protective and curative effects against konjac soft rot. Further mechanistic analysis reveal that KSM disrupts key gene expression associated with membrane transport in <i>P. aroidearum</i>, leading to inhibited swimming motility, reduced production of virulence factors, and significant alterations in cell morphology. These findings highlight the antibacterial properties of KSM against <i>P. aroidearum</i>, offering valuable insights into its potential application for treating bacterial soft rot in konjac.</p>

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Kasugamycin disrupts membrane transport and reduces virulence in Pectobacterium aroidearum to control konjac soft rot

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月26日

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  • Chunlan Xiong,
  • Xue Zhou,
  • Yupei Tu,
  • Yu Zhu,
  • Xiaojuan Du,
  • Kaihuai Li,
  • Fengquan Liu

摘要

Konjac (Amorphophallus konjac) is an important food crop and a traditional medicinal herb in China. However, bacterial soft rot poses a serious threat to konjac production and quality. In this study, we identified Pectobacterium aroidearum as the causative pathogen of soft rot in konjac and investigated the antibacterial effects of kasugamycin (KSM) against this bacterium. Our results show that KSM exhibits strong antibacterial activity, significantly reducing the virulence of P. aroidearum and providing both protective and curative effects against konjac soft rot. Further mechanistic analysis reveal that KSM disrupts key gene expression associated with membrane transport in P. aroidearum, leading to inhibited swimming motility, reduced production of virulence factors, and significant alterations in cell morphology. These findings highlight the antibacterial properties of KSM against P. aroidearum, offering valuable insights into its potential application for treating bacterial soft rot in konjac.