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Background <p>Guidelines generally advise against reperfusion therapy in patients with mild stroke (NIHSS ≤ 5) and non-disabling symptoms. However, stroke severity can fluctuate, and clinical scores may not fully capture tissue at risk. Reliance on non-contrast CT (NCCT), potentially missing perfusion deficits or large vessel occlusions (LVOs). Advanced imaging—including CT angiography (CTA) and CT perfusion (CTP)—can reveal significant hypoperfusion in otherwise mild presentations. This study aimed to quantify the proportion of increased tissue-at-risk volumes (Tmax + 6s ≥ 15 mL) in patients with mild acute ischaemic stroke and identify associated factors and outcomes.</p> Methods <p>We included consecutive AIS patients within 24&#xa0;h of onset from multicentre stroke registries in Australia and Indonesia. Only those with baseline NCCT, CTA, and CTP were analysed. Patients were stratified into NIHSS ≤ 5 and &gt; 5. Tissue-at-risk was defined as Tmax + 6s ≥ 15 mL. Clinical, imaging, and outcome data were compared, and predictors of poor functional outcome (mRS 3–6 at 90-day) were assessed.</p> Results <p>Of 655 patients, 314 had NIHSS ≤ 5. Among these, 22.9% exhibited Tmax + 6s ≥ 15 mL, indicating significant hypoperfusion. This subgroup had worse 90-day outcomes (26.4% mRS 3–6 vs. 9.5%, <i>p</i> &lt; 0.001). Tmax + 6s ≥ 15 mL, hypertension, and LVO were independently associated with poor outcome (adjusted ORs: 2.51, 3.15, and 2.74 respectively). ROC analysis demonstrated moderate discrimination of Tmax + 6s volume for poor functional outcome.</p> Conclusions <p>A substantial proportion of mild stroke patients harbour treatable perfusion deficits. CT perfusion provides essential prognostic information beyond clinical severity, supporting its role in guiding therapeutic decisions—even in low NIHSS presentations where standard imaging may otherwise overlook tissue at risk.</p>

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CT perfusion identified potential treatment opportunities in one in five mild strokes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月7日

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  • Yohanna Kusuma,
  • Bizhong Che,
  • Presaad Pillai,
  • Ximing Nie,
  • Leonard Yeo LL,
  • Vijay K. Sharma,
  • Andrew Wong,
  • Peter Riley,
  • Benjamin Clissold,
  • Paul Talman,
  • Mursyid Bustami,
  • Lyna Soertidewi,
  • M. Arief R. Kemal,
  • Indah A. Putri,
  • Reza Aditya Arpandy,
  • Nandini Phalita Laksmi,
  • Nurul Rakhmawati,
  • Paul Yielder,
  • Bernard Yan

摘要

Background

Guidelines generally advise against reperfusion therapy in patients with mild stroke (NIHSS ≤ 5) and non-disabling symptoms. However, stroke severity can fluctuate, and clinical scores may not fully capture tissue at risk. Reliance on non-contrast CT (NCCT), potentially missing perfusion deficits or large vessel occlusions (LVOs). Advanced imaging—including CT angiography (CTA) and CT perfusion (CTP)—can reveal significant hypoperfusion in otherwise mild presentations. This study aimed to quantify the proportion of increased tissue-at-risk volumes (Tmax + 6s ≥ 15 mL) in patients with mild acute ischaemic stroke and identify associated factors and outcomes.

Methods

We included consecutive AIS patients within 24 h of onset from multicentre stroke registries in Australia and Indonesia. Only those with baseline NCCT, CTA, and CTP were analysed. Patients were stratified into NIHSS ≤ 5 and > 5. Tissue-at-risk was defined as Tmax + 6s ≥ 15 mL. Clinical, imaging, and outcome data were compared, and predictors of poor functional outcome (mRS 3–6 at 90-day) were assessed.

Results

Of 655 patients, 314 had NIHSS ≤ 5. Among these, 22.9% exhibited Tmax + 6s ≥ 15 mL, indicating significant hypoperfusion. This subgroup had worse 90-day outcomes (26.4% mRS 3–6 vs. 9.5%, p < 0.001). Tmax + 6s ≥ 15 mL, hypertension, and LVO were independently associated with poor outcome (adjusted ORs: 2.51, 3.15, and 2.74 respectively). ROC analysis demonstrated moderate discrimination of Tmax + 6s volume for poor functional outcome.

Conclusions

A substantial proportion of mild stroke patients harbour treatable perfusion deficits. CT perfusion provides essential prognostic information beyond clinical severity, supporting its role in guiding therapeutic decisions—even in low NIHSS presentations where standard imaging may otherwise overlook tissue at risk.