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Background <p>Oxidative stress and inflammation contribute to telomere length (TL) attrition, a hallmark of cellular senescence. Systemic lupus erythematosus (SLE) is associated with premature cellular aging; however, the clinical relevance of TL shortening remains unclear. This study aimed to compare the relative TL of SLE patients and healthy controls and explore its association with clinical features and disease burden.</p> Methods <p>We conducted a cross-sectional study including adult SLE patients and age- and sex-matched healthy controls (18–60 years). Demographic and clinical data were collected, and TL was measured using quantitative polymerase chain reaction (qPCR). Among SLE patients, disease activity, cumulative damage, fatigue, depression, anxiety, stress, and physical activity were also assessed. Statistical analyses included descriptive statistics, Student’s t-test or Mann-Whitney test for group comparisons, Spearman’s correlation, and multiple linear regression models selected based on the lowest Akaike information criterion (AIC).</p> Results <p>Sixty SLE patients (37 years ± 11.5) and 55 controls (38 years ± 10.5) were enrolled. SLE patients exhibited significantly shorter TL [median (IQR): 0.80 (0.29–2.94)] compared to controls [1.07 (0.38–2.32); <i>p</i> = 0.005]. In multivariate analysis, moderate anxiety was associated with shorter TL compared to none/low anxiety [β= -0.353 (95%CI: -0.645; -0.061); <i>p</i> = 0.019]. An alternative model indicated that moderate stress was also associated with reduced TL [β= -0.411 (95%CI: -0.771; -0.050); <i>p</i> = 0.026]. No significant associations were found between TL and disease activity or cumulative damage.</p> Conclusions <p>SLE patients presented significantly shorter telomeres than healthy controls, with anxiety and stress symptoms contributing to TL attrition. Longitudinal studies are warranted to elucidate the clinical implications of TL shortening in SLE.</p>

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Shortened telomere length, anxiety and psychological stress in systemic lupus erythematosus: a cross-sectional study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月17日

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  • Anna Carolina Faria Moreira Gomes Tavares,
  • Carolina Ruas Freire Santos,
  • Jéssica Martins Amaral,
  • Ivonne Carolina Bolaños Burgos,
  • Daniela Valadão Freitas Rosa,
  • Marco Aurélio Romano-Silva,
  • Maria Aparecida Camargos Bicalho,
  • Gilda Aparecida Ferreira,
  • Adriana Maria Kakehasi

摘要

Background

Oxidative stress and inflammation contribute to telomere length (TL) attrition, a hallmark of cellular senescence. Systemic lupus erythematosus (SLE) is associated with premature cellular aging; however, the clinical relevance of TL shortening remains unclear. This study aimed to compare the relative TL of SLE patients and healthy controls and explore its association with clinical features and disease burden.

Methods

We conducted a cross-sectional study including adult SLE patients and age- and sex-matched healthy controls (18–60 years). Demographic and clinical data were collected, and TL was measured using quantitative polymerase chain reaction (qPCR). Among SLE patients, disease activity, cumulative damage, fatigue, depression, anxiety, stress, and physical activity were also assessed. Statistical analyses included descriptive statistics, Student’s t-test or Mann-Whitney test for group comparisons, Spearman’s correlation, and multiple linear regression models selected based on the lowest Akaike information criterion (AIC).

Results

Sixty SLE patients (37 years ± 11.5) and 55 controls (38 years ± 10.5) were enrolled. SLE patients exhibited significantly shorter TL [median (IQR): 0.80 (0.29–2.94)] compared to controls [1.07 (0.38–2.32); p = 0.005]. In multivariate analysis, moderate anxiety was associated with shorter TL compared to none/low anxiety [β= -0.353 (95%CI: -0.645; -0.061); p = 0.019]. An alternative model indicated that moderate stress was also associated with reduced TL [β= -0.411 (95%CI: -0.771; -0.050); p = 0.026]. No significant associations were found between TL and disease activity or cumulative damage.

Conclusions

SLE patients presented significantly shorter telomeres than healthy controls, with anxiety and stress symptoms contributing to TL attrition. Longitudinal studies are warranted to elucidate the clinical implications of TL shortening in SLE.