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Background <p>Epilepsy is a well-known, prevalent chronic disorder primarily caused by neuroinflammation resulting from various progressive neurological conditions and ultimately leading to recurrent seizures. Drug-resistant epilepsy represents a significant challenge in treatment, affecting approximately one-third of patients. Introducing a natural treatment to reduce either epileptic seizures or the associated neuroinflammation could help patients avoid the side effects of conventional drugs.</p> Results <p>The current study investigates the effects of frankincense oil (FO) in attenuating epileptic seizures by modulating inflammatory and antioxidant mediators in the brain tissue of rats. Status epilepticus (SE) was induced by a single high dose of penicillin. Typical epileptic seizure episodes were observed 30 min after administering penicillin to the SE epileptic group of rats. However, the rats that received an oral dose of frankincense oil prior to the penicillin administration showed no epileptic symptoms. The anti-inflammatory and antioxidant effects of frankincense oil were confirmed by analyzing its ability to inhibit various mediators associated with neuroinflammation and oxidative stress, such as NF-kB, IL-6, IL-12, TNFα, IFNγ, COX2, CXCL1, CXCL8, and prostaglandin, while activating IL-10.</p> Conclusions <p>FO is attenuating neuroinflammation associated with seizure progression in rats. In addition, it exhibits anti-inflammatory and antioxidant properties that help mitigate brain neurotoxicity.</p>

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Frankincense oil as a novel modulator of epileptic-associated neuroinflammation induced by penicillin in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月15日

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  • Mohamed E. Elhadidy,
  • Mohamed S. Taha,
  • Asmaa A. Salem,
  • Gihan M. Hammoud

摘要

Background

Epilepsy is a well-known, prevalent chronic disorder primarily caused by neuroinflammation resulting from various progressive neurological conditions and ultimately leading to recurrent seizures. Drug-resistant epilepsy represents a significant challenge in treatment, affecting approximately one-third of patients. Introducing a natural treatment to reduce either epileptic seizures or the associated neuroinflammation could help patients avoid the side effects of conventional drugs.

Results

The current study investigates the effects of frankincense oil (FO) in attenuating epileptic seizures by modulating inflammatory and antioxidant mediators in the brain tissue of rats. Status epilepticus (SE) was induced by a single high dose of penicillin. Typical epileptic seizure episodes were observed 30 min after administering penicillin to the SE epileptic group of rats. However, the rats that received an oral dose of frankincense oil prior to the penicillin administration showed no epileptic symptoms. The anti-inflammatory and antioxidant effects of frankincense oil were confirmed by analyzing its ability to inhibit various mediators associated with neuroinflammation and oxidative stress, such as NF-kB, IL-6, IL-12, TNFα, IFNγ, COX2, CXCL1, CXCL8, and prostaglandin, while activating IL-10.

Conclusions

FO is attenuating neuroinflammation associated with seizure progression in rats. In addition, it exhibits anti-inflammatory and antioxidant properties that help mitigate brain neurotoxicity.