Scholarlink

Background <p>Isthmic Spondylolisthesis (IS) is characterized by the displacement of vertebral bones. Tranexamic acid (TXA), an antifibrinolytic agent, is used to mitigate intraoperative blood loss and the need for blood transfusions during spine surgery. This study aimed to compare the effectiveness of prophylactic TXA in reducing blood loss between the two distinct methods of treatment.</p> Methods <p>One hundred patients who underwent lumbar IS fusion were divided into two groups. Fifty patients underwent posterolateral fusion )PLF(, while the remaining 50 underwent surgery with posterior lumbar interbody fusion instruments (PLIF). Both groups received intravenous TXA as a 15&#xa0;mg/kg bolus at anesthetic induction, followed by a continuous maintenance infusion of 1&#xa0;mg/kg/h during surgery. Blood samples were collected at 24 and 48&#xa0;h postoperatively to measure complete blood count (CBC), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen levels, sodium, potassium, calcium, platelet count, blood transfusion requirements, and blood loss.</p> Results <p>At baseline, there was no significant difference between the two groups, except for a longer duration of surgery in the PLIF group (<i>P</i> = 0.000). Following TXA treatment, there were no significant differences in recovery parameters, CBC parameters, PT, PTT, or fibrinogen levels in the arterial blood between the two groups. A significant difference was observed in urine volume during surgery, although no significant difference was observed in blood loss.</p> Conclusion <p>The study found that no significant intergroup differences were observed in CBC, PT, PTT, fibrinogen levels, and blood loss during surgery after the TXA administration.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prophylactic effects of tranexamic acid in spinal fusion: comparing blood loss and transfusion requirements in PLF vs. PLIF for isthmic spondylolisthesis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月25日

查看全文
  • Majid Reza Farrokhi,
  • Seyed Reza Mousavi,
  • Mahshid Hosseini,
  • Kamran Hosseini

摘要

Background

Isthmic Spondylolisthesis (IS) is characterized by the displacement of vertebral bones. Tranexamic acid (TXA), an antifibrinolytic agent, is used to mitigate intraoperative blood loss and the need for blood transfusions during spine surgery. This study aimed to compare the effectiveness of prophylactic TXA in reducing blood loss between the two distinct methods of treatment.

Methods

One hundred patients who underwent lumbar IS fusion were divided into two groups. Fifty patients underwent posterolateral fusion )PLF(, while the remaining 50 underwent surgery with posterior lumbar interbody fusion instruments (PLIF). Both groups received intravenous TXA as a 15 mg/kg bolus at anesthetic induction, followed by a continuous maintenance infusion of 1 mg/kg/h during surgery. Blood samples were collected at 24 and 48 h postoperatively to measure complete blood count (CBC), prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen levels, sodium, potassium, calcium, platelet count, blood transfusion requirements, and blood loss.

Results

At baseline, there was no significant difference between the two groups, except for a longer duration of surgery in the PLIF group (P = 0.000). Following TXA treatment, there were no significant differences in recovery parameters, CBC parameters, PT, PTT, or fibrinogen levels in the arterial blood between the two groups. A significant difference was observed in urine volume during surgery, although no significant difference was observed in blood loss.

Conclusion

The study found that no significant intergroup differences were observed in CBC, PT, PTT, fibrinogen levels, and blood loss during surgery after the TXA administration.