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<p>Multifocal and multicentric glioblastoma (mGBM) present significant challenges for surgical resection and impact patient outcomes. Recent studies have shown a positive correlation between the extent of resection (EOR) and functional outcomes in mGBM cases. Techniques such as fluorescence-guided surgery (FGS) and targeted therapies that focus on tumor-associated macrophages and immune pathways may enhance both survival rates and quality of life for these patients. Additionally, maximizing the extent of resection, conducting intraoperative mapping, and implementing rehabilitation strategies can further improve functional outcomes. However, more research is necessary to develop tailored treatment strategies that optimize patient outcomes in mGBM.</p>

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Letter to the editor: “Multifocal and multicentric glioblastoma: clinical characteristics and treatment outcomes.”

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月4日

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  • Aymen Siddique,
  • Aqsa Tasaddeq

摘要

Multifocal and multicentric glioblastoma (mGBM) present significant challenges for surgical resection and impact patient outcomes. Recent studies have shown a positive correlation between the extent of resection (EOR) and functional outcomes in mGBM cases. Techniques such as fluorescence-guided surgery (FGS) and targeted therapies that focus on tumor-associated macrophages and immune pathways may enhance both survival rates and quality of life for these patients. Additionally, maximizing the extent of resection, conducting intraoperative mapping, and implementing rehabilitation strategies can further improve functional outcomes. However, more research is necessary to develop tailored treatment strategies that optimize patient outcomes in mGBM.