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Background <p>Heat can help control the progression of intra-axial cerebral neoplasms in selected cases. RF (Radiofrequency) is available and cost effective in resource-limited settings. RF stereotactic heat was delivered simultaneously with the biopsy in brain tumors.</p> Objective <p>We evaluated the safety and feasibility of stereotactic RF ablation of intra-axial brain neoplasms during stereotactic brain biopsy procedure.</p> Methods <p>Twenty-two adult patients were treated with interstitial hyperthermia by RF plus stereotactic brain tumor biopsy in Ain shams University Hospitals from 2022 to 2024. Follow-up for tumor progression was done over a period of 12&#xa0;months.</p> Results <p>A total of 22 participants have been enrolled; follow-up period was 12&#xa0;months. There were 12 (54.5%) females and 10 (45.5%) males. The mean and median ages were 53.6&#xa0;years (range 25–72) and 54&#xa0;years, respectively. 72.6% had at least a single baseline comorbidity. From the ablated tumors, 17 were primary, 4 were metastatic, and 1 was in-field necrosis. Median tumor volume was 6 cm<sup>3</sup> and mean was 10.2 cm<sup>3</sup>&#xa0;(range, 0.5–40 cm<sup>3</sup>). The one-year estimated survival rate was 86.6%, and this was impacted by disease etiology.</p> Conclusions <p>Results from this study demonstrate that RF ablation is a safe technique that it can be used simultaneously with stereotactic biopsy in selected cases of intra-axial brain neoplasms. A potential trend of longer progression-free interval of tumor is presumed in the cases. In resource-limited settings, RF ablation can be a safe and available alternative to LITT (Laser Interstitial Thermocoagulative Therapy) that can deliver heat to intracranial tumors.</p>

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The role of simultaneous stereotactic biopsy and radiofrequency ablation in the management of brain neoplasms in countries with limited financial resources

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月4日

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  • Mohamed Ashraf Mahmoud,
  • Abdelrahman El Gayar,
  • Shafik T El Molla,
  • Hesham Radwan,
  • Tarek H El Serry,
  • Ashraf Al Abyad

摘要

Background

Heat can help control the progression of intra-axial cerebral neoplasms in selected cases. RF (Radiofrequency) is available and cost effective in resource-limited settings. RF stereotactic heat was delivered simultaneously with the biopsy in brain tumors.

Objective

We evaluated the safety and feasibility of stereotactic RF ablation of intra-axial brain neoplasms during stereotactic brain biopsy procedure.

Methods

Twenty-two adult patients were treated with interstitial hyperthermia by RF plus stereotactic brain tumor biopsy in Ain shams University Hospitals from 2022 to 2024. Follow-up for tumor progression was done over a period of 12 months.

Results

A total of 22 participants have been enrolled; follow-up period was 12 months. There were 12 (54.5%) females and 10 (45.5%) males. The mean and median ages were 53.6 years (range 25–72) and 54 years, respectively. 72.6% had at least a single baseline comorbidity. From the ablated tumors, 17 were primary, 4 were metastatic, and 1 was in-field necrosis. Median tumor volume was 6 cm3 and mean was 10.2 cm3 (range, 0.5–40 cm3). The one-year estimated survival rate was 86.6%, and this was impacted by disease etiology.

Conclusions

Results from this study demonstrate that RF ablation is a safe technique that it can be used simultaneously with stereotactic biopsy in selected cases of intra-axial brain neoplasms. A potential trend of longer progression-free interval of tumor is presumed in the cases. In resource-limited settings, RF ablation can be a safe and available alternative to LITT (Laser Interstitial Thermocoagulative Therapy) that can deliver heat to intracranial tumors.