Scholarlink

Background <p>Migraine involves complex neurovascular mechanisms with evidence of brainstem dysfunction, particularly in auditory processing. Comparative data between migraine with aura (MA) and without aura (MoA) using detailed electrophysiological and psychoacoustic assessments are limited. In this study, we aim to compare auditory brainstem function in MA and MoA patients and healthy controls and assess correlations with migraine characteristics.</p> Methods <p>Forty-one migraine patients (18 MA, 23 MoA) and 41 matched controls with normal peripheral hearing underwent clinical evaluation, Arabic Central Auditory Processing Disorder (CAPD) questionnaire, basic audiologic testing, masking level difference (MLD) at 500&#xa0;Hz and 1000&#xa0;Hz, and auditory brainstem responses (ABR) at low and high repetition rates. ABR parameters included absolute latencies (Waves I, III, V), interpeak intervals, and V/I amplitude ratios.</p> Results <p>Basic audiologic measures Pure-Tone Average (PTA), Speech Reception Threshold (SRT), Word Discrimination (WD) were normal in all participants. Migraineurs showed significantly higher MLD scores than controls (MLD 500: 9.3 ± 1.7 vs. 4.5 ± 1.4 dB; MLD 1000: 9.5 ± 1.7 vs. 4.6 ± 1.2 dB; <i>p</i> &lt; 0.001). ABR revealed prolonged latencies (LIII, LV, HI–V) and interpeak intervals (LIII–V, LI–V) in migraine (<i>p</i> &lt; 0.001), indicating central auditory brainstem dysfunction. Compared to MoA, MA patients had longer LV (<i>p</i> = 0.041) and greater interaural amplitude asymmetry (LHV1a, <i>p</i> = 0.035). In MA, ABR latencies correlated strongly with attack frequency and disability by using Migraine Disability Assessment (MIDAS) (<i>r</i> = 0.78–0.84, <i>p</i> &lt; 0.01).</p> Conclusion <p>Both MA and MoA present with central auditory brainstem abnormalities despite normal peripheral hearing. MA shows subtle but significant prolongations in brainstem conduction and asymmetry, which correlate with clinical severity. These findings address a gap in migraine research by providing subtype-specific electrophysiological evidence, supporting the potential use of ABR parameters particularly latency of wave III, V, IV and interpeak interval I–V as objective biomarkers for disease monitoring and targeted intervention.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Auditory brainstem function in migraine with aura and without aura: a comparative study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月2日

查看全文
  • Mohammad S. Ali,
  • Hayam Abdel-Tawab,
  • Soliman S. Ghanem,
  • Ibrahim H. Abd-Elhamid,
  • Hossam A. Hussein,
  • Eman A. Elhamrawy,
  • Tamer El-Esawy Abdel-Moaaty,
  • Rania Abdelshafy,
  • Marwa H. Abo Omirah,
  • Ahmed I. Abbas

摘要

Background

Migraine involves complex neurovascular mechanisms with evidence of brainstem dysfunction, particularly in auditory processing. Comparative data between migraine with aura (MA) and without aura (MoA) using detailed electrophysiological and psychoacoustic assessments are limited. In this study, we aim to compare auditory brainstem function in MA and MoA patients and healthy controls and assess correlations with migraine characteristics.

Methods

Forty-one migraine patients (18 MA, 23 MoA) and 41 matched controls with normal peripheral hearing underwent clinical evaluation, Arabic Central Auditory Processing Disorder (CAPD) questionnaire, basic audiologic testing, masking level difference (MLD) at 500 Hz and 1000 Hz, and auditory brainstem responses (ABR) at low and high repetition rates. ABR parameters included absolute latencies (Waves I, III, V), interpeak intervals, and V/I amplitude ratios.

Results

Basic audiologic measures Pure-Tone Average (PTA), Speech Reception Threshold (SRT), Word Discrimination (WD) were normal in all participants. Migraineurs showed significantly higher MLD scores than controls (MLD 500: 9.3 ± 1.7 vs. 4.5 ± 1.4 dB; MLD 1000: 9.5 ± 1.7 vs. 4.6 ± 1.2 dB; p < 0.001). ABR revealed prolonged latencies (LIII, LV, HI–V) and interpeak intervals (LIII–V, LI–V) in migraine (p < 0.001), indicating central auditory brainstem dysfunction. Compared to MoA, MA patients had longer LV (p = 0.041) and greater interaural amplitude asymmetry (LHV1a, p = 0.035). In MA, ABR latencies correlated strongly with attack frequency and disability by using Migraine Disability Assessment (MIDAS) (r = 0.78–0.84, p < 0.01).

Conclusion

Both MA and MoA present with central auditory brainstem abnormalities despite normal peripheral hearing. MA shows subtle but significant prolongations in brainstem conduction and asymmetry, which correlate with clinical severity. These findings address a gap in migraine research by providing subtype-specific electrophysiological evidence, supporting the potential use of ABR parameters particularly latency of wave III, V, IV and interpeak interval I–V as objective biomarkers for disease monitoring and targeted intervention.