Scholarlink

Background <p>Myasthenia gravis (MG) is an autoimmune disorder characterized mainly by muscle weakness with physical exertion. There is conflicting data about the presence of cognitive dysfunction in MG<Emphasis Type="BoldItalic">,</Emphasis> hence we conducted this study to assess the cognitive functions in patients with MG, and find possible predictors for cognitive impairment in MG patients.</p> Results <p>A cross-sectional study, where 50 MG patients were recruited consecutively. Patients were diagnosed with MG based on clinical, neurophysiological and laboratorial basis. Their cognitive functions were evaluated via The Arabic Version Montreal Cognitive Assessment (MOCA) and the Arabic Version of Addenbrooke’s Cognitive Examination-III. Moreover, we evaluated patient's Quality of life, Insomnia, and depression via The Arabic version of Myasthenia Gravis Activity Day living (MG-ADL), Insomnia Severity Index (ISI), and the Beck Depression Inventory (BDI) respectively. MG patients had a mean age of 35 ± 12.7 years, majority of patients suffered ocular symptoms (88%). positive ACHR antibody was detected in 80% of patients. MCI was found in 42% of patients, where the visuospatial/executive domains were the most affected. Cognitive impairment correlated with fewer education years, disease duration, severity, elevated AChR antibody titers, and prolonged steroid use. Significant predictors for MCI included bulbar symptoms, MG-ADL score.</p> Conclusion <p>MCI could be common in patients with MG. Bulbar symptoms, the length of steroid use, the level of ACHR antibodies, disease severity, prolonged duration, insomnia, and depression could contribute to an elevated risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mild cognitive impairment and its predictors in patients with Myasthenia Gravis.

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月2日

查看全文
  • Yasmin Abd El Hady Mohamed El Mahrouky,
  • Naglaa Mohamed El Khayat,
  • Ahmed Mohamed Hazzou,
  • Radwa Soliman

摘要

Background

Myasthenia gravis (MG) is an autoimmune disorder characterized mainly by muscle weakness with physical exertion. There is conflicting data about the presence of cognitive dysfunction in MG, hence we conducted this study to assess the cognitive functions in patients with MG, and find possible predictors for cognitive impairment in MG patients.

Results

A cross-sectional study, where 50 MG patients were recruited consecutively. Patients were diagnosed with MG based on clinical, neurophysiological and laboratorial basis. Their cognitive functions were evaluated via The Arabic Version Montreal Cognitive Assessment (MOCA) and the Arabic Version of Addenbrooke’s Cognitive Examination-III. Moreover, we evaluated patient's Quality of life, Insomnia, and depression via The Arabic version of Myasthenia Gravis Activity Day living (MG-ADL), Insomnia Severity Index (ISI), and the Beck Depression Inventory (BDI) respectively. MG patients had a mean age of 35 ± 12.7 years, majority of patients suffered ocular symptoms (88%). positive ACHR antibody was detected in 80% of patients. MCI was found in 42% of patients, where the visuospatial/executive domains were the most affected. Cognitive impairment correlated with fewer education years, disease duration, severity, elevated AChR antibody titers, and prolonged steroid use. Significant predictors for MCI included bulbar symptoms, MG-ADL score.

Conclusion

MCI could be common in patients with MG. Bulbar symptoms, the length of steroid use, the level of ACHR antibodies, disease severity, prolonged duration, insomnia, and depression could contribute to an elevated risk.