Scholarlink

Background <p>Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome following IV rt-PA treatment in a group of Egyptian patients with acute ischemic stroke (AIS). We included sixty patients diagnosed with AIS who met the criteria for IV rt-PA therapy. Data were collected and statistically analyzed, we established correlations with functional outcomes as measured by the modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) 3-month post-treatment.</p> Results <p>Of the 60 patients, 40 (66.67%) exhibited a favorable functional outcome, while 20 (33.33%) experienced a less favorable outcome. Poor functional outcome was associated with atrial fibrillation [<i>p</i> value &lt; 0.001, odds ratio (OR) 6.28], hypertension (<i>p</i> value = 0.001, OR 3.65), diabetes mellitus (<i>p</i> value 0.009, OR 2.805), and a higher NIHSS at admission (<i>p</i> value = 0.003, OR 8.03).</p> Conclusions <p>Certain factors may affect functional outcome in stroke patients treated with rt-PA therapy. There are strong associations between hypertension, diabetes, atrial fibrillation, post-rt-PA intracerebral hemorrhage (both asymptomatic and symptomatic), specific stroke subtypes, and less favorable functional outcome 3 months after rt-PA administration, as measured by the mRS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictors of clinical outcome in post-thrombolysis among sample of Egyptian patients with acute ischemic stroke

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月6日

查看全文
  • AbdelRahman Mohamed Hussein,
  • Iman Mohamed Bayoumy,
  • Khaled Ossama Abdulghani,
  • Mona Ali Eissa,
  • Ehab Mostafa Ahmed,
  • Ali Ahmed Abou Elmaaty

摘要

Background

Stroke stands as a major cause of morbidity and mortality worldwide. The recommended treatment for eligible patients within the initial 4.5-h window is intravenous recombinant tissue plasminogen activator (IV rt-PA). This study explored the factors influencing functional outcome following IV rt-PA treatment in a group of Egyptian patients with acute ischemic stroke (AIS). We included sixty patients diagnosed with AIS who met the criteria for IV rt-PA therapy. Data were collected and statistically analyzed, we established correlations with functional outcomes as measured by the modified Rankin Scale (mRS) and National Institute of Health Stroke Scale (NIHSS) 3-month post-treatment.

Results

Of the 60 patients, 40 (66.67%) exhibited a favorable functional outcome, while 20 (33.33%) experienced a less favorable outcome. Poor functional outcome was associated with atrial fibrillation [p value < 0.001, odds ratio (OR) 6.28], hypertension (p value = 0.001, OR 3.65), diabetes mellitus (p value 0.009, OR 2.805), and a higher NIHSS at admission (p value = 0.003, OR 8.03).

Conclusions

Certain factors may affect functional outcome in stroke patients treated with rt-PA therapy. There are strong associations between hypertension, diabetes, atrial fibrillation, post-rt-PA intracerebral hemorrhage (both asymptomatic and symptomatic), specific stroke subtypes, and less favorable functional outcome 3 months after rt-PA administration, as measured by the mRS.