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Background <p>Widely used antineoplastic drugs, including vincristine (VCT), are known to be genotoxic and cause side effects in humans and animals. Consequently, there is a need to explore the antineoplastic potential of notable medicinal plants. This study investigated the role of <i>Tridax procumbens</i> (TDP), a medicinal plant with beneficial ethnopharmacological properties, on VCT-induced genotoxicity and histological alterations in male Wistar rats.</p> Methods <p>Forty male Wistar rats were equally divided into eight groups (A–H) and treated as follows: Group A (control) received 1 mL/kg distilled water, Group B: VCT (0.1 mg/kg), Groups C–E: TDP (50, 100, and 200 mg/kg), and Groups F–H: VCT plus TDP at the varying doses. The treatment lasted for ten days, after which histological examinations and genotoxicity tests were conducted.</p> Results <p>There was a significant (<i>p</i> &lt; 0.05) reduction in the body weight change of VCT-treated rats. On the contrary, TDP dose-dependently increased the body weight of treated rats. VCT induced notable histological changes in the testes, epididymis, and kidneys, which were ameliorated in the groups co-treated with TDP. VCT also significantly (<i>p</i> &lt; 0.05) increased micronucleus formation and macrophage infiltration in the bone marrow compared to the control. Co-treatment with TDP dose-dependently reduced these effects.</p> Conclusion <p>These findings suggest that <i>Tridax procumbens</i> may offer protective effects against VCT-induced disruption in organ weight changes, histological alterations, and genotoxicity parameters, highlighting its potential use as an alternative or adjunct anticancer agent.</p>

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Attenuation of vincristine-induced genotoxicity and histological derangements by Tridax procumbens leaf extract in male Wistar rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月29日

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  • Ekundayo Samuel,
  • Emmanuel Ajisope,
  • Olabode Olabintan,
  • Itunuoluwa Olugbenga

摘要

Background

Widely used antineoplastic drugs, including vincristine (VCT), are known to be genotoxic and cause side effects in humans and animals. Consequently, there is a need to explore the antineoplastic potential of notable medicinal plants. This study investigated the role of Tridax procumbens (TDP), a medicinal plant with beneficial ethnopharmacological properties, on VCT-induced genotoxicity and histological alterations in male Wistar rats.

Methods

Forty male Wistar rats were equally divided into eight groups (A–H) and treated as follows: Group A (control) received 1 mL/kg distilled water, Group B: VCT (0.1 mg/kg), Groups C–E: TDP (50, 100, and 200 mg/kg), and Groups F–H: VCT plus TDP at the varying doses. The treatment lasted for ten days, after which histological examinations and genotoxicity tests were conducted.

Results

There was a significant (p < 0.05) reduction in the body weight change of VCT-treated rats. On the contrary, TDP dose-dependently increased the body weight of treated rats. VCT induced notable histological changes in the testes, epididymis, and kidneys, which were ameliorated in the groups co-treated with TDP. VCT also significantly (p < 0.05) increased micronucleus formation and macrophage infiltration in the bone marrow compared to the control. Co-treatment with TDP dose-dependently reduced these effects.

Conclusion

These findings suggest that Tridax procumbens may offer protective effects against VCT-induced disruption in organ weight changes, histological alterations, and genotoxicity parameters, highlighting its potential use as an alternative or adjunct anticancer agent.