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Background <p>Different chemical substances are used by the humans in their daily life for different purposes. Most of them are synthetic and have severe after effects to the living beings. Pesticides are such chemical products which are synthesized to control different pests. Pesticide induced toxicity affects different organs system of living beings including humans. There is the need to find the solution especially from the natural resources to overcome the toxic effects exerted by such chemicals. The study was conducted to assess the toxicity of lindane to the brain of exposed animals. The protective effect of aqueous ginger (AQ) as an antioxidant in the Wistar rats of both the sexes was also evaluated in this study.</p> Results <p>The oxidative stress markers were found to be disturbed in the brain samples of animals exposed to pesticide lindane. The disturbed oxidative markers by the exposure to lindane such as lipid peroxidation, reduced glutathione, glutathione reductase, glutathione peroxidase, superoxide dismutase, catalase and reactive oxygen species (ROS) level were found to be improved after treatment with aqueous ginger. The female sex of experimental animals was affected more in contrast to male sex but the difference was statistically insignificant.</p> Conclusion <p>Pesticide toxicity can be ameliorated by the use of ginger by improving the levels of antioxidants of the recipient. Therefore, this indicates the antioxidative effects of aqueous ginger against pesticide induced toxicity.</p>

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Use of aqueous ginger as an antioxidant against organochlorine pesticide poisoning in male and female Wistar rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月28日

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  • Poonam Keshav,
  • Deepak Kumar Goyal,
  • Santosh Singh,
  • Puneet Bhardwaj

摘要

Background

Different chemical substances are used by the humans in their daily life for different purposes. Most of them are synthetic and have severe after effects to the living beings. Pesticides are such chemical products which are synthesized to control different pests. Pesticide induced toxicity affects different organs system of living beings including humans. There is the need to find the solution especially from the natural resources to overcome the toxic effects exerted by such chemicals. The study was conducted to assess the toxicity of lindane to the brain of exposed animals. The protective effect of aqueous ginger (AQ) as an antioxidant in the Wistar rats of both the sexes was also evaluated in this study.

Results

The oxidative stress markers were found to be disturbed in the brain samples of animals exposed to pesticide lindane. The disturbed oxidative markers by the exposure to lindane such as lipid peroxidation, reduced glutathione, glutathione reductase, glutathione peroxidase, superoxide dismutase, catalase and reactive oxygen species (ROS) level were found to be improved after treatment with aqueous ginger. The female sex of experimental animals was affected more in contrast to male sex but the difference was statistically insignificant.

Conclusion

Pesticide toxicity can be ameliorated by the use of ginger by improving the levels of antioxidants of the recipient. Therefore, this indicates the antioxidative effects of aqueous ginger against pesticide induced toxicity.