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Background <p>The objective of this study was to characterise the agreement of the CE-certified automated robotic ultrasound system ARTHUR v.2.0, combined with the AI model DIANA v.2.0, for grading osteophytes in hand osteoarthritis (OA), using expert rheumatologist assessment as the reference standard.</p> Methods <p>Thirty patients with hand OA underwent ultrasound of MCP, PIP, and DIP joints with ARTHUR v.2.0 and subsequently by an expert rheumatologist. Osteophytes were graded (0–3) using the OMERACT system. Agreement was assessed using weighted Cohen’s kappa (κ), Percent Exact Agreement (PEA), Percent Close Agreement (PCA), sensitivity, and specificity. Comparisons were made against both the primary rheumatologist and an independent blinded external assessor (EA).</p> Results <p>ARTHUR v.2.0 successfully scanned 703/840 joints (83.7%), with lower success in DIP joints. Agreement between ARTHUR+DIANA and the rheumatologist showed κ = 0.49, PEA 53.7%, and PCA 90.7%. Compared to the EA, the automated system showed κ = 0.46 and PCA 90.5%. Agreement between the rheumatologist and EA showed κ = 0.67 and PCA 97.5%. Binary agreement for disease presence (≥ Grade 2) for the automated system was 81.6% compared to the rheumatologist, although sensitivity was limited (36.5%).</p> Conclusions <p>ARTHUR v.2.0 combined with DIANA v.2.0 achieved binary agreement comparable to expert–expert comparisons, although with limited sensitivity, and moderate agreement on the full 0–3 OMERACT scale. A decomposition analysis indicated that acquisition-related variability contributed substantially to the overall discrepancy. Refinement of AI threshold calibration and distal joint acquisition, and evaluation in larger and more diverse cohorts, is warranted to further improve sensitivity for osteophyte detection.</p>

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Automated ultrasound with AI for osteophyte grading in hand osteoarthritis: comparison with expert rheumatologist assessment

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月21日

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  • Bill Aplin Frederiksen,
  • Hilde Berner Hammer,
  • Lene Terslev,
  • Mads Ammitzbøll Danielsen,
  • Thiusius Rajeeth Savarimuthu,
  • Anders Bossel Holst Weber,
  • Søren Andreas Just

摘要

Background

The objective of this study was to characterise the agreement of the CE-certified automated robotic ultrasound system ARTHUR v.2.0, combined with the AI model DIANA v.2.0, for grading osteophytes in hand osteoarthritis (OA), using expert rheumatologist assessment as the reference standard.

Methods

Thirty patients with hand OA underwent ultrasound of MCP, PIP, and DIP joints with ARTHUR v.2.0 and subsequently by an expert rheumatologist. Osteophytes were graded (0–3) using the OMERACT system. Agreement was assessed using weighted Cohen’s kappa (κ), Percent Exact Agreement (PEA), Percent Close Agreement (PCA), sensitivity, and specificity. Comparisons were made against both the primary rheumatologist and an independent blinded external assessor (EA).

Results

ARTHUR v.2.0 successfully scanned 703/840 joints (83.7%), with lower success in DIP joints. Agreement between ARTHUR+DIANA and the rheumatologist showed κ = 0.49, PEA 53.7%, and PCA 90.7%. Compared to the EA, the automated system showed κ = 0.46 and PCA 90.5%. Agreement between the rheumatologist and EA showed κ = 0.67 and PCA 97.5%. Binary agreement for disease presence (≥ Grade 2) for the automated system was 81.6% compared to the rheumatologist, although sensitivity was limited (36.5%).

Conclusions

ARTHUR v.2.0 combined with DIANA v.2.0 achieved binary agreement comparable to expert–expert comparisons, although with limited sensitivity, and moderate agreement on the full 0–3 OMERACT scale. A decomposition analysis indicated that acquisition-related variability contributed substantially to the overall discrepancy. Refinement of AI threshold calibration and distal joint acquisition, and evaluation in larger and more diverse cohorts, is warranted to further improve sensitivity for osteophyte detection.