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<p>Medulloblastoma is a heterogeneous central nervous system tumor stratified into four molecular subgroups in the revised 2021 WHO classification. Although MRI remains essential for follow-up, distinguishing true recurrence from treatment-related changes can be challenging. PET imaging may provide additional value in this context; however, evidence in medulloblastoma is limited to small series and case reports, with most available PET data originating from glioma studies. Here, we report a medulloblastoma patient experiencing two recurrences assessed sequentially with 18F-FDOPA and 18F-FDG PET imaging. This case highlights considerations in PET tracer selection, aiming to support clinical decision-making and enhance diagnostic accuracy for physicians managing recurrent medulloblastoma.</p>

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18F-FDG versus 18F-FDOPA PET in recurrent medulloblastoma: a case study and literature review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月13日

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  • Abarnaa Sivapathasundaram,
  • Florence Laigle-Donadey,
  • Catherine Horodyckid,
  • Karima Mokhtari,
  • Aurélie Kas,
  • Laura Rozenblum

摘要

Medulloblastoma is a heterogeneous central nervous system tumor stratified into four molecular subgroups in the revised 2021 WHO classification. Although MRI remains essential for follow-up, distinguishing true recurrence from treatment-related changes can be challenging. PET imaging may provide additional value in this context; however, evidence in medulloblastoma is limited to small series and case reports, with most available PET data originating from glioma studies. Here, we report a medulloblastoma patient experiencing two recurrences assessed sequentially with 18F-FDOPA and 18F-FDG PET imaging. This case highlights considerations in PET tracer selection, aiming to support clinical decision-making and enhance diagnostic accuracy for physicians managing recurrent medulloblastoma.