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<p>Capivasertib has emerged as a promising treatment for advanced breast and prostate cancer. Here, we report two cases of metastatic breast cancer patients who developed splenic hypermetabolism on [18&#xa0;F]-FDG PET/CT following treatment with capivasertib. To our knowledge, these are the first documented instances of this treatment-related phenomenon. Although the mechanism behind this side effect remains unclear, these cases highlight an important imaging phenomenon that radiologists should consider when interpreting [18&#xa0;F]-FDG PET/CT scans in patients treated with capivasertib.</p>

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Capivasertib treatment associated with hypermetabolism of the spleen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月24日

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  • Maria Ly,
  • Gary Z. Yu,
  • Amin Haghighat Jahromi

摘要

Capivasertib has emerged as a promising treatment for advanced breast and prostate cancer. Here, we report two cases of metastatic breast cancer patients who developed splenic hypermetabolism on [18 F]-FDG PET/CT following treatment with capivasertib. To our knowledge, these are the first documented instances of this treatment-related phenomenon. Although the mechanism behind this side effect remains unclear, these cases highlight an important imaging phenomenon that radiologists should consider when interpreting [18 F]-FDG PET/CT scans in patients treated with capivasertib.